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GDF15-From Biomarker to Allostatic Hormone.
O'Rahilly S. O'Rahilly S. Cell Metab. 2017 Dec 5;26(6):807-808. doi: 10.1016/j.cmet.2017.10.017. Epub 2017 Nov 28. Cell Metab. 2017. PMID: 29195860 Free article.
GDF15 mediates the effects of metformin on body weight and energy balance.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S. Coll AP, et al. Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25. Nature. 2020. PMID: 31875646 Free PMC article. Clinical Trial.
Colchicine-an old dog with new tricks.
Lockhart SM, O'Rahilly S. Lockhart SM, et al. Nat Metab. 2021 Apr;3(4):451-452. doi: 10.1038/s42255-021-00360-4. Nat Metab. 2021. PMID: 33846642 No abstract available.
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee EC, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jørgensen SB, Coll AP, Breen DM, O'Rahilly S. Cimino I, et al. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106868118. doi: 10.1073/pnas.2106868118. Proc Natl Acad Sci U S A. 2021. PMID: 34187898 Free PMC article.
Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice.
Patel S, Haider A, Alvarez-Guaita A, Bidault G, El-Sayed Moustafa JS, Guiu-Jurado E, Tadross JA, Warner J, Harrison J, Virtue S, Scurria F, Zvetkova I, Blüher M, Small KS, O'Rahilly S, Savage DB. Patel S, et al. Mol Metab. 2022 Nov;65:101589. doi: 10.1016/j.molmet.2022.101589. Epub 2022 Sep 2. Mol Metab. 2022. PMID: 36064109 Free PMC article.
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S. Fejzo M, et al. Among authors: o rahilly s. Nature. 2024 Jan;625(7996):760-767. doi: 10.1038/s41586-023-06921-9. Epub 2023 Dec 13. Nature. 2024. PMID: 38092039 Free PMC article.
553 results