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Identification of potent inhibitors of the sortilin-progranulin interaction.
Stachel SJ, Ginnetti AT, Johnson SA, Cramer P, Wang Y, Bukhtiyarova M, Krosky D, Stump C, Hurzy DM, Schlegel KA, Cooke AJ, Allen S, O'Donnell G, Ziebell M, Parthasarathy G, Getty KL, Ho T, Ou Y, Jovanovska A, Carroll SS, Pausch M, Lumb K, Mosser SD, Voleti B, Klein DJ, Soisson SM, Zerbinatti C, Coleman PJ. Stachel SJ, et al. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403. doi: 10.1016/j.bmcl.2020.127403. Epub 2020 Jul 15. Bioorg Med Chem Lett. 2020. PMID: 32738972
Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening.
Kutchukian PS, Warren L, Magliaro BC, Amoss A, Cassaday JA, O'Donnell G, Squadroni B, Zuck P, Pascarella D, Culberson JC, Cooke AJ, Hurzy D, Schlegel KS, Thomson F, Johnson EN, Uebele VN, Hermes JD, Parmentier-Batteur S, Finley M. Kutchukian PS, et al. ACS Chem Biol. 2017 Feb 17;12(2):519-527. doi: 10.1021/acschembio.6b00913. Epub 2017 Jan 6. ACS Chem Biol. 2017. PMID: 28032990 Free article.
Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2.
Wen X, Liu C, Ghislain L, Tovar K, Shah V, Stout SJ, Cifelli S, Satapati S, O'Donnell G, Sheth PR, Wildey MJ, Datwani SS, Covey TR, Bateman KP, McLaren DG. Wen X, et al. Anal Chem. 2021 Apr 20;93(15):6071-6079. doi: 10.1021/acs.analchem.0c04312. Epub 2021 Apr 5. Anal Chem. 2021. PMID: 33819010
Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.
Pertusi DA, O'Donnell G, Homsher MF, Solly K, Patel A, Stahler SL, Riley D, Finley MF, Finger EN, Adam GC, Meng J, Bell DJ, Zuck PD, Hudak EM, Weber MJ, Nothstein JE, Locco L, Quinn C, Amoss A, Squadroni B, Hartnett M, Heo MR, White T, May SA, Boots E, Roberts K, Cocchiarella P, Wolicki A, Kreamer A, Kutchukian PS, Wassermann AM, Uebele VN, Glick M, Rusinko A 3rd, Culberson JC. Pertusi DA, et al. SLAS Discov. 2017 Sep;22(8):995-1006. doi: 10.1177/2472555217706058. Epub 2017 Apr 20. SLAS Discov. 2017. PMID: 28426940 Free article.
A high-precision fluorogenic cholesteryl ester transfer protein assay compatible with animal serum and 3456-well assay technology.
Eveland SS, Milot DP, Guo Q, Chen Y, Hyland SA, Peterson LB, Jezequel-Sur S, O'Donnell GT, Zuck PD, Ferrer M, Strulovici B, Wagner JA, Tanaka WK, Hilliard DA, Laterza O, Wright SD, Sparrow CP, Anderson MS. Eveland SS, et al. Anal Biochem. 2007 Sep 15;368(2):239-49. doi: 10.1016/j.ab.2007.06.003. Epub 2007 Jun 8. Anal Biochem. 2007. PMID: 17601482
61 results