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Page 1
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans.
Arunachalam PS, Wimmers F, Mok CKP, Perera RAPM, Scott M, Hagan T, Sigal N, Feng Y, Bristow L, Tak-Yin Tsang O, Wagh D, Coller J, Pellegrini KL, Kazmin D, Alaaeddine G, Leung WS, Chan JMC, Chik TSH, Choi CYC, Huerta C, Paine McCullough M, Lv H, Anderson E, Edupuganti S, Upadhyay AA, Bosinger SE, Maecker HT, Khatri P, Rouphael N, Peiris M, Pulendran B. Arunachalam PS, et al. Among authors: upadhyay aa. Science. 2020 Sep 4;369(6508):1210-1220. doi: 10.1126/science.abc6261. Epub 2020 Aug 11. Science. 2020. PMID: 32788292 Free PMC article.
Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures.
Vanderheiden A, Ralfs P, Chirkova T, Upadhyay AA, Zimmerman MG, Bedoya S, Aoued H, Tharp GM, Pellegrini KL, Manfredi C, Sorscher E, Mainou B, Lobby JL, Kohlmeier JE, Lowen AC, Shi PY, Menachery VD, Anderson LJ, Grakoui A, Bosinger SE, Suthar MS. Vanderheiden A, et al. Among authors: upadhyay aa. J Virol. 2020 Sep 15;94(19):e00985-20. doi: 10.1128/JVI.00985-20. Print 2020 Sep 15. J Virol. 2020. PMID: 32699094 Free PMC article.
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Hoang TN, Pino M, Boddapati AK, Viox EG, Starke CE, Upadhyay AA, Gumber S, Busman-Sahay K, Strongin Z, Harper JL, Tharp GK, Pellegrini KL, Kirejczyk S, Zandi K, Tao S, Horton TR, Beagle EN, Mahar EA, Lee MY, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Delmas OM, Wang S, Cooney KA, Sayegh MN, Wang L, Weiskopf D, Filev PD, Waggoner J, Piantadosi A, Kasturi SP, Al-Shakhshir H, Ribeiro SP, Sekaly RP, Levit RD, Estes JD, Vanderford TH, Schinazi RF, Bosinger SE, Paiardini M. Hoang TN, et al. Among authors: upadhyay aa. bioRxiv [Preprint]. 2020 Sep 16:2020.09.16.300277. doi: 10.1101/2020.09.16.300277. bioRxiv. 2020. PMID: 32995780 Free PMC article. Updated. Preprint.
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Hoang TN, Pino M, Boddapati AK, Viox EG, Starke CE, Upadhyay AA, Gumber S, Nekorchuk M, Busman-Sahay K, Strongin Z, Harper JL, Tharp GK, Pellegrini KL, Kirejczyk S, Zandi K, Tao S, Horton TR, Beagle EN, Mahar EA, Lee MYH, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Delmas OM, Wang S, Cooney KA, Sayegh MN, Wang L, Filev PD, Weiskopf D, Silvestri G, Waggoner J, Piantadosi A, Kasturi SP, Al-Shakhshir H, Ribeiro SP, Sekaly RP, Levit RD, Estes JD, Vanderford TH, Schinazi RF, Bosinger SE, Paiardini M. Hoang TN, et al. Among authors: upadhyay aa. Cell. 2021 Jan 21;184(2):460-475.e21. doi: 10.1016/j.cell.2020.11.007. Epub 2020 Nov 10. Cell. 2021. PMID: 33278358 Free PMC article.
A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
Routhu NK, Cheedarla N, Gangadhara S, Bollimpelli VS, Boddapati AK, Shiferaw A, Rahman SA, Sahoo A, Edara VV, Lai L, Floyd K, Wang S, Fischinger S, Atyeo C, Shin SA, Gumber S, Kirejczyk S, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Upadhyay AA, Pellegrini K, Montefiori D, Shi PY, Menachery VD, Alter G, Vanderford TH, Bosinger SE, Suthar MS, Amara RR. Routhu NK, et al. Among authors: upadhyay aa. Immunity. 2021 Mar 9;54(3):542-556.e9. doi: 10.1016/j.immuni.2021.02.001. Epub 2021 Feb 4. Immunity. 2021. PMID: 33631118 Free PMC article.
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.
Hoang TN, Viox EG, Upadhyay AA, Strongin Z, Tharp GK, Pino M, Nchioua R, Hirschenberger M, Gagne M, Nguyen K, Harper JL, Marciano S, Boddapati AK, Pellegrini KL, Tisoncik-Go J, Whitmore LS, Karunakaran KA, Roy M, Kirejczyk S, Curran EH, Wallace C, Wood JS, Connor-Stroud F, Kasturi SP, Levit RD, Gale M Jr, Vanderford TH, Silvestri G, Busman-Sahay K, Estes JD, Vaccari M, Douek DC, Sparrer KMJ, Kirchhoff F, Johnson RP, Schreiber G, Bosinger SE, Paiardini M. Hoang TN, et al. Among authors: upadhyay aa. bioRxiv [Preprint]. 2022 Oct 24:2022.10.21.512606. doi: 10.1101/2022.10.21.512606. bioRxiv. 2022. PMID: 36324810 Free PMC article. Updated. Preprint.
TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques.
Upadhyay AA, Viox EG, Hoang TN, Boddapati AK, Pino M, Lee MY, Corry J, Strongin Z, Cowan DA, Beagle EN, Horton TR, Hamilton S, Aoued H, Harper JL, Edwards CT, Nguyen K, Pellegrini KL, Tharp GK, Piantadosi A, Levit RD, Amara RR, Barratt-Boyes SM, Ribeiro SP, Sekaly RP, Vanderford TH, Schinazi RF, Paiardini M, Bosinger SE. Upadhyay AA, et al. Nat Commun. 2023 Apr 6;14(1):1914. doi: 10.1038/s41467-023-37425-9. Nat Commun. 2023. PMID: 37024448 Free PMC article.
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.
Viox EG, Hoang TN, Upadhyay AA, Nchioua R, Hirschenberger M, Strongin Z, Tharp GK, Pino M, Nguyen K, Harper JL, Gagne M, Marciano S, Boddapati AK, Pellegrini KL, Pradhan A, Tisoncik-Go J, Whitmore LS, Karunakaran KA, Roy M, Kirejczyk S, Curran EH, Wallace C, Wood JS, Connor-Stroud F, Voigt EA, Monaco CM, Gordon DE, Kasturi SP, Levit RD, Gale M Jr, Vanderford TH, Silvestri G, Busman-Sahay K, Estes JD, Vaccari M, Douek DC, Sparrer KMJ, Johnson RP, Kirchhoff F, Schreiber G, Bosinger SE, Paiardini M. Viox EG, et al. Among authors: upadhyay aa. Sci Immunol. 2023 Jul 28;8(85):eadg0033. doi: 10.1126/sciimmunol.adg0033. Epub 2023 Jul 28. Sci Immunol. 2023. PMID: 37506197 Free PMC article.
Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.
Lee MY, Upadhyay AA, Walum H, Chan CN, Dawoud RA, Grech C, Harper JL, Karunakaran KA, Nelson SA, Mahar EA, Goss KL, Carnathan DG, Cervasi B, Gill K, Tharp GK, Wonderlich ER, Velu V, Barratt-Boyes SM, Paiardini M, Silvestri G, Estes JD, Bosinger SE. Lee MY, et al. Among authors: upadhyay aa. PLoS Pathog. 2021 Jun 28;17(6):e1009674. doi: 10.1371/journal.ppat.1009674. eCollection 2021 Jun. PLoS Pathog. 2021. PMID: 34181694 Free PMC article.
35 results