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Page 1
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Ndoja A, Reja R, Lee SH, Webster JD, Ngu H, Rose CM, Kirkpatrick DS, Modrusan Z, Chen YJ, Dugger DL, Gandham V, Xie L, Newton K, Dixit VM. Ndoja A, et al. Among authors: reja r. Cell. 2020 Sep 3;182(5):1156-1169.e12. doi: 10.1016/j.cell.2020.07.011. Epub 2020 Aug 13. Cell. 2020. PMID: 32795415 Free article.
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.
Newton K, Dugger DL, Sengupta-Ghosh A, Ferrando RE, Chu F, Tao J, Lam W, Haller S, Chan S, Sa S, Dunlap D, Eastham-Anderson J, Ngu H, Hung J, French DM, Webster JD, Bolon B, Liu J, Reja R, Kummerfeld S, Chen YJ, Modrusan Z, Lewcock JW, Dixit VM. Newton K, et al. Among authors: reja r. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11244-11249. doi: 10.1073/pnas.1805033115. Epub 2018 Oct 15. Proc Natl Acad Sci U S A. 2018. PMID: 30322923 Free PMC article.
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.
Abed M, Verschueren E, Budayeva H, Liu P, Kirkpatrick DS, Reja R, Kummerfeld SK, Webster JD, Gierke S, Reichelt M, Anderson KR, Newman RJ, Roose-Girma M, Modrusan Z, Pektas H, Maltepe E, Newton K, Dixit VM. Abed M, et al. Among authors: reja r. PLoS One. 2019 Apr 5;14(4):e0214110. doi: 10.1371/journal.pone.0214110. eCollection 2019. PLoS One. 2019. PMID: 30951545 Free PMC article.
The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.
Oberbeck N, Pham VC, Webster JD, Reja R, Huang CS, Zhang Y, Roose-Girma M, Warming S, Li Q, Birnberg A, Wong W, Sandoval W, Kőműves LG, Yu K, Dugger DL, Maltzman A, Newton K, Dixit VM. Oberbeck N, et al. Among authors: reja r. Nature. 2019 Oct;574(7777):249-253. doi: 10.1038/s41586-019-1615-3. Epub 2019 Oct 2. Nature. 2019. PMID: 31578523
Activity of caspase-8 determines plasticity between cell death pathways.
Newton K, Wickliffe KE, Maltzman A, Dugger DL, Reja R, Zhang Y, Roose-Girma M, Modrusan Z, Sagolla MS, Webster JD, Dixit VM. Newton K, et al. Among authors: reja r. Nature. 2019 Nov;575(7784):679-682. doi: 10.1038/s41586-019-1752-8. Epub 2019 Nov 13. Nature. 2019. PMID: 31723262
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.
Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, Reja R, Cheung TK, Liang Y, Webster JD, Lehoux I, Skippington E, Reeder J, Haley B, Tan MW, Rose CM, Newton K, Kayagaki N, Vance RE, Dixit VM. Luchetti G, et al. Among authors: reja r. Cell Host Microbe. 2021 Oct 13;29(10):1521-1530.e10. doi: 10.1016/j.chom.2021.08.010. Epub 2021 Sep 6. Cell Host Microbe. 2021. PMID: 34492225 Free PMC article.
Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
Gitlin AD, Heger K, Schubert AF, Reja R, Yan D, Pham VC, Suto E, Zhang J, Kwon YC, Freund EC, Kang J, Pham A, Caothien R, Bacarro N, Hinkle T, Xu M, McKenzie BS, Haley B, Lee WP, Lill JR, Roose-Girma M, Dohse M, Webster JD, Newton K, Dixit VM. Gitlin AD, et al. Among authors: reja r. Nature. 2020 Nov;587(7833):275-280. doi: 10.1038/s41586-020-2796-5. Epub 2020 Sep 24. Nature. 2020. PMID: 32971525
IRF2 transcriptionally induces GSDMD expression for pyroptosis.
Kayagaki N, Lee BL, Stowe IB, Kornfeld OS, O'Rourke K, Mirrashidi KM, Haley B, Watanabe C, Roose-Girma M, Modrusan Z, Kummerfeld S, Reja R, Zhang Y, Cho V, Andrews TD, Morris LX, Goodnow CC, Bertram EM, Dixit VM. Kayagaki N, et al. Among authors: reja r. Sci Signal. 2019 May 21;12(582):eaax4917. doi: 10.1126/scisignal.aax4917. Sci Signal. 2019. PMID: 31113851
NINJ1 mediates plasma membrane rupture during lytic cell death.
Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, Li Q, Sandoval W, Yan D, Kang J, Xu M, Zhang J, Lee WP, McKenzie BS, Ulas G, Payandeh J, Roose-Girma M, Modrusan Z, Reja R, Sagolla M, Webster JD, Cho V, Andrews TD, Morris LX, Miosge LA, Goodnow CC, Bertram EM, Dixit VM. Kayagaki N, et al. Among authors: reja r. Nature. 2021 Mar;591(7848):131-136. doi: 10.1038/s41586-021-03218-7. Epub 2021 Jan 20. Nature. 2021. PMID: 33472215
34 results