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Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment.
Clin Cancer Res. 2020 Dec 1;26(23):6284-6298. doi: 10.1158/1078-0432.CCR-20-0472. Epub 2020 Aug 17.
Clin Cancer Res. 2020.
PMID: 32817076
A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist.
Leyland R, Watkins A, Mulgrew KA, Holoweckyj N, Bamber L, Tigue NJ, Offer E, Andrews J, Yan L, Mullins S, Oberst MD, Coates Ulrichsen J, Leinster DA, McGlinchey K, Young L, Morrow M, Hammond SA, Mallinder P, Herath A, Leow CC, Wilkinson RW, Stewart R.
Leyland R, et al. Among authors: leinster da.
Clin Cancer Res. 2017 Jul 1;23(13):3416-3427. doi: 10.1158/1078-0432.CCR-16-2000. Epub 2017 Jan 9.
Clin Cancer Res. 2017.
PMID: 28069723
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Interleukin-6 Stimulates Defective Angiogenesis.
Gopinathan G, Milagre C, Pearce OM, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR, Balkwill F.
Gopinathan G, et al. Among authors: leinster da.
Cancer Res. 2015 Aug 1;75(15):3098-107. doi: 10.1158/0008-5472.CAN-15-1227. Epub 2015 Jun 16.
Cancer Res. 2015.
PMID: 26081809
Free PMC article.
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Interleukin-6 as a therapeutic target in human ovarian cancer.
Coward J, Kulbe H, Chakravarty P, Leader D, Vassileva V, Leinster DA, Thompson R, Schioppa T, Nemeth J, Vermeulen J, Singh N, Avril N, Cummings J, Rexhepaj E, Jirström K, Gallagher WM, Brennan DJ, McNeish IA, Balkwill FR.
Coward J, et al. Among authors: leinster da.
Clin Cancer Res. 2011 Sep 15;17(18):6083-96. doi: 10.1158/1078-0432.CCR-11-0945. Epub 2011 Jul 27.
Clin Cancer Res. 2011.
PMID: 21795409
Free PMC article.
Clinical Trial.
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A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L; Australian Ovarian Cancer Study Group; Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR.
Kulbe H, et al. Among authors: leinster da.
Cancer Res. 2012 Jan 1;72(1):66-75. doi: 10.1158/0008-5472.CAN-11-2178. Epub 2011 Nov 7.
Cancer Res. 2012.
PMID: 22065722
Free PMC article.
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The peritoneal tumour microenvironment of high-grade serous ovarian cancer.
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FN, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S, Balkwill FR.
Leinster DA, et al.
J Pathol. 2012 Jun;227(2):136-45. doi: 10.1002/path.4002. Epub 2012 Apr 18.
J Pathol. 2012.
PMID: 22322968
Free PMC article.
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Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK.
Hagemann T, Wilson J, Kulbe H, Li NF, Leinster DA, Charles K, Klemm F, Pukrop T, Binder C, Balkwill FR.
Hagemann T, et al. Among authors: leinster da.
J Immunol. 2005 Jul 15;175(2):1197-205. doi: 10.4049/jimmunol.175.2.1197.
J Immunol. 2005.
PMID: 16002723
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Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.
Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T, Imhof BA, Balkwill FR, Nourshargh S.
Leinster DA, et al.
FASEB J. 2013 Oct;27(10):4244-53. doi: 10.1096/fj.13-230441. Epub 2013 Jul 3.
FASEB J. 2013.
PMID: 23825230
Free PMC article.
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