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Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD.
Jensen VS, Fledelius C, Zachodnik C, Damgaard J, Nygaard H, Tornqvist KS, Kirk RK, Viuff BM, Wulff EM, Lykkesfeldt J, Hvid H. Jensen VS, et al. Among authors: fledelius c. J Transl Med. 2021 Feb 17;19(1):80. doi: 10.1186/s12967-021-02729-1. J Transl Med. 2021. PMID: 33596938 Free PMC article.
Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models.
Jensen VS, Tveden-Nyborg P, Zacho-Rasmussen C, Quaade ML, Ipsen DH, Hvid H, Fledelius C, Wulff EM, Lykkesfeldt J. Jensen VS, et al. Among authors: fledelius c. J Pharmacol Toxicol Methods. 2020 Jan-Feb;101:106651. doi: 10.1016/j.vascn.2019.106651. Epub 2019 Nov 13. J Pharmacol Toxicol Methods. 2020. PMID: 31733366 Free article.
Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes.
Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Allen EJ, Donahue EP, Rivera N, Winnick JJ, Edgerton DS, Nishimura E, Fledelius C, Brand CL, Cherrington AD. Gregory JM, et al. Among authors: fledelius c. Diabetes. 2015 Oct;64(10):3439-51. doi: 10.2337/db15-0071. Epub 2015 Jun 17. Diabetes. 2015. PMID: 26085570 Free PMC article.
Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs.
Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Madsen P, Kjeldsen TB, Hostrup S, Brand CL, Fledelius C, Nishimura E, Cherrington AD. Gregory JM, et al. Among authors: fledelius c. Diabetes Obes Metab. 2019 Oct;21(10):2294-2304. doi: 10.1111/dom.13808. Epub 2019 Jul 8. Diabetes Obes Metab. 2019. PMID: 31183936 Free PMC article.
Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans.
Kjeldsen TB, Hubálek F, Hjørringgaard CU, Tagmose TM, Nishimura E, Stidsen CE, Porsgaard T, Fledelius C, Refsgaard HHF, Gram-Nielsen S, Naver H, Pridal L, Hoeg-Jensen T, Jeppesen CB, Manfè V, Ludvigsen S, Lautrup-Larsen I, Madsen P. Kjeldsen TB, et al. Among authors: fledelius c. J Med Chem. 2021 Jul 8;64(13):8942-8950. doi: 10.1021/acs.jmedchem.1c00257. Epub 2021 May 4. J Med Chem. 2021. PMID: 33944562 Free article.
55 results