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Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, van der Heden van Noort GJ, Geurink PP, Ovaa H, Newman J, Riboldi-Tunnicliffe A, Czabotar PE, Mitchell JP, Feltham R, Lechtenberg BC, Lowes KN, Dewson G, Pellegrini M, Lessene G, Komander D. Klemm T, et al. Among authors: dewson g. EMBO J. 2020 Sep 15;39(18):e106275. doi: 10.15252/embj.2020106275. Epub 2020 Aug 26. EMBO J. 2020. PMID: 32845033 Free PMC article.
Molecular biology of Bax and Bak activation and action.
Westphal D, Dewson G, Czabotar PE, Kluck RM. Westphal D, et al. Among authors: dewson g. Biochim Biophys Acta. 2011 Apr;1813(4):521-31. doi: 10.1016/j.bbamcr.2010.12.019. Epub 2010 Dec 30. Biochim Biophys Acta. 2011. PMID: 21195116 Free article. Review.
Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.
Westphal D, Dewson G, Menard M, Frederick P, Iyer S, Bartolo R, Gibson L, Czabotar PE, Smith BJ, Adams JM, Kluck RM. Westphal D, et al. Among authors: dewson g. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4076-85. doi: 10.1073/pnas.1415142111. Epub 2014 Sep 16. Proc Natl Acad Sci U S A. 2014. PMID: 25228770 Free PMC article.
Physiological restraint of Bak by Bcl-xL is essential for cell survival.
Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Lee EF, et al. Among authors: dewson g. Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19. Genes Dev. 2016. PMID: 27198225 Free PMC article.
Parkin and mitophagy in cancer.
Bernardini JP, Lazarou M, Dewson G. Bernardini JP, et al. Among authors: dewson g. Oncogene. 2017 Mar;36(10):1315-1327. doi: 10.1038/onc.2016.302. Epub 2016 Sep 5. Oncogene. 2017. PMID: 27593930 Review.
91 results