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Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.
George SL, Lorenzi F, King D, Hartlieb S, Campbell J, Pemberton H, Toprak UH, Barker K, Tall J, da Costa BM, van den Boogaard ML, Dolman MEM, Molenaar JJ, Bryant HE, Westermann F, Lord CJ, Chesler L. George SL, et al. Among authors: toprak uh. EBioMedicine. 2020 Sep;59:102971. doi: 10.1016/j.ebiom.2020.102971. Epub 2020 Aug 23. EBioMedicine. 2020. PMID: 32846370 Free PMC article.
FOXR2 Stabilizes MYCN Protein and Identifies Non-MYCN-Amplified Neuroblastoma Patients With Unfavorable Outcome.
Schmitt-Hoffner F, van Rijn S, Toprak UH, Mauermann M, Rosemann F, Heit-Mondrzyk A, Hübner JM, Camgöz A, Hartlieb S, Pfister SM, Henrich KO, Westermann F, Kool M. Schmitt-Hoffner F, et al. Among authors: toprak uh. J Clin Oncol. 2021 Oct 10;39(29):3217-3228. doi: 10.1200/JCO.20.02540. Epub 2021 Jun 10. J Clin Oncol. 2021. PMID: 34110923 Free PMC article.
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb SA, Sieverling L, Nadler-Holly M, Ziehm M, Toprak UH, Herrmann C, Ishaque N, Okonechnikov K, Gartlgruber M, Park YG, Wecht EM, Savelyeva L, Henrich KO, Rosswog C, Fischer M, Hero B, Jones DTW, Pfaff E, Witt O, Pfister SM, Volckmann R, Koster J, Kiesel K, Rippe K, Taschner-Mandl S, Ambros P, Brors B, Selbach M, Feuerbach L, Westermann F. Hartlieb SA, et al. Among authors: toprak uh. Nat Commun. 2021 Feb 24;12(1):1269. doi: 10.1038/s41467-021-21247-8. Nat Commun. 2021. PMID: 33627664 Free PMC article.
Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma.
Afanasyeva EA, Gartlgruber M, Ryl T, Decaesteker B, Denecker G, Mönke G, Toprak UH, Florez A, Torkov A, Dreidax D, Herrmann C, Okonechnikov K, Ek S, Sharma AK, Sagulenko V, Speleman F, Henrich KO, Westermann F. Afanasyeva EA, et al. Among authors: toprak uh. Life Sci Alliance. 2021 Mar 3;4(5):e201900332. doi: 10.26508/lsa.201900332. Print 2021 May. Life Sci Alliance. 2021. PMID: 33658318 Free PMC article.
Super enhancers define regulatory subtypes and cell identity in neuroblastoma.
Gartlgruber M, Sharma AK, Quintero A, Dreidax D, Jansky S, Park YG, Kreth S, Meder J, Doncevic D, Saary P, Toprak UH, Ishaque N, Afanasyeva E, Wecht E, Koster J, Versteeg R, Grünewald TGP, Jones DTW, Pfister SM, Henrich KO, van Nes J, Herrmann C, Westermann F. Gartlgruber M, et al. Among authors: toprak uh. Nat Cancer. 2021 Jan;2(1):114-128. doi: 10.1038/s43018-020-00145-w. Epub 2020 Dec 7. Nat Cancer. 2021. PMID: 35121888
Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities.
Giesen N, Paramasivam N, Toprak UH, Huebschmann D, Xu J, Uhrig S, Samur M, Bähr S, Fröhlich M, Mughal SS, Mai EK, Jauch A, Müller-Tidow C, Brors B, Munshi N, Goldschmidt H, Weinhold N, Schlesner M, Raab MS. Giesen N, et al. Among authors: toprak uh. Haematologica. 2022 Aug 1;107(8):1891-1901. doi: 10.3324/haematol.2021.279360. Haematologica. 2022. PMID: 35045690 Free PMC article.
Mutational patterns and regulatory networks in epigenetic subgroups of meningioma.
Paramasivam N, Hübschmann D, Toprak UH, Ishaque N, Neidert M, Schrimpf D, Stichel D, Reuss D, Sievers P, Reinhardt A, Wefers AK, Jones DTW, Gu Z, Werner J, Uhrig S, Wirsching HG, Schick M, Bewerunge-Hudler M, Beck K, Brehmer S, Urbschat S, Seiz-Rosenhagen M, Hänggi D, Herold-Mende C, Ketter R, Eils R, Ram Z, Pfister SM, Wick W, Weller M, Grossmann R, von Deimling A, Schlesner M, Sahm F. Paramasivam N, et al. Among authors: toprak uh. Acta Neuropathol. 2019 Aug;138(2):295-308. doi: 10.1007/s00401-019-02008-w. Epub 2019 May 8. Acta Neuropathol. 2019. PMID: 31069492
Pan-cancer analysis of whole genomes.
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. Epub 2020 Feb 5. Nature. 2020. PMID: 32025007 Free PMC article.
102 results