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Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype.
Weber L, Frati G, Felix T, Hardouin G, Casini A, Wollenschlaeger C, Meneghini V, Masson C, De Cian A, Chalumeau A, Mavilio F, Amendola M, Andre-Schmutz I, Cereseto A, El Nemer W, Concordet JP, Giovannangeli C, Cavazzana M, Miccio A. Weber L, et al. Among authors: de cian a. Sci Adv. 2020 Feb 12;6(7):eaay9392. doi: 10.1126/sciadv.aay9392. Print 2020 Feb. Sci Adv. 2020. PMID: 32917636 Free PMC article.
Combination of lentiviral and genome editing technologies for the treatment of sickle cell disease.
Ramadier S, Chalumeau A, Felix T, Othman N, Aknoun S, Casini A, Maule G, Masson C, De Cian A, Frati G, Brusson M, Concordet JP, Cavazzana M, Cereseto A, El Nemer W, Amendola M, Wattellier B, Meneghini V, Miccio A. Ramadier S, et al. Among authors: de cian a. Mol Ther. 2022 Jan 5;30(1):145-163. doi: 10.1016/j.ymthe.2021.08.019. Epub 2021 Aug 19. Mol Ther. 2022. PMID: 34418541 Free PMC article.
Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.
Renaud JB, Boix C, Charpentier M, De Cian A, Cochennec J, Duvernois-Berthet E, Perrouault L, Tesson L, Edouard J, Thinard R, Cherifi Y, Menoret S, Fontanière S, de Crozé N, Fraichard A, Sohm F, Anegon I, Concordet JP, Giovannangeli C. Renaud JB, et al. Among authors: de croze n, de cian a. Cell Rep. 2016 Mar 8;14(9):2263-2272. doi: 10.1016/j.celrep.2016.02.018. Epub 2016 Feb 25. Cell Rep. 2016. PMID: 26923600 Free article.
Genome Editing in Rats Using TALE Nucleases.
Tesson L, Remy S, Ménoret S, Usal C, Thinard R, Savignard C, De Cian A, Giovannangeli C, Concordet JP, Anegon I. Tesson L, et al. Among authors: de cian a. Methods Mol Biol. 2016;1338:245-59. doi: 10.1007/978-1-4939-2932-0_18. Methods Mol Biol. 2016. PMID: 26443226
Cancer translocations in human cells induced by zinc finger and TALE nucleases.
Piganeau M, Ghezraoui H, De Cian A, Guittat L, Tomishima M, Perrouault L, René O, Katibah GE, Zhang L, Holmes MC, Doyon Y, Concordet JP, Giovannangeli C, Jasin M, Brunet E. Piganeau M, et al. Among authors: de cian a. Genome Res. 2013 Jul;23(7):1182-93. doi: 10.1101/gr.147314.112. Epub 2013 Apr 8. Genome Res. 2013. PMID: 23568838 Free PMC article.
Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins.
Ménoret S, De Cian A, Tesson L, Remy S, Usal C, Boulé JB, Boix C, Fontanière S, Crénéguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I. Ménoret S, et al. Among authors: de cian a. Sci Rep. 2015 Oct 7;5:14410. doi: 10.1038/srep14410. Sci Rep. 2015. PMID: 26442875 Free PMC article.
64 results