Dai J - Search Results

1

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA_A receptor positive allosteric modulator.

Althaus AL, Ackley MA, Belfort GM, Gee SM, Dai J, Nguyen DP, Kazdoba TM, Modgil A, Davies PA, Moss SJ, Salituro FG, Hoffmann E, Hammond RS, Robichaud AJ, Quirk MC, Doherty JJ. Althaus AL, et al. Among authors: dai j. Neuropharmacology. 2020 Dec 15;181:108333. doi: 10.1016/j.neuropharm.2020.108333. Epub 2020 Sep 22. Neuropharmacology. 2020. PMID: 32976892 Free PMC article.

2

Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)_A Receptor.

Martinez Botella G, Salituro FG, Harrison BL, Beresis RT, Bai Z, Blanco MJ, Belfort GM, Dai J, Loya CM, Ackley MA, Althaus AL, Grossman SJ, Hoffmann E, Doherty JJ, Robichaud AJ. Martinez Botella G, et al. Among authors: dai j. J Med Chem. 2017 Sep 28;60(18):7810-7819. doi: 10.1021/acs.jmedchem.7b00846. Epub 2017 Aug 17. J Med Chem. 2017. PMID: 28753313

3

A new method for determining levels of sedation in dogs: A pilot study with propofol and a novel neuroactive steroid anesthetic.

Youngblood BL, Ueyama Y, Muir WW, Belfort GM, Hammond RH, Dai J, Salituro FG, Robichaud AJ, Doherty JJ. Youngblood BL, et al. Among authors: dai j. J Neurosci Methods. 2018 Jul 15;305:82-88. doi: 10.1016/j.jneumeth.2018.05.006. Epub 2018 May 23. J Neurosci Methods. 2018. PMID: 29772269

4

Neuroactive Steroid N-Methyl-d-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity.

La DS, Salituro FG, Martinez Botella G, Griffin AM, Bai Z, Ackley MA, Dai J, Doherty JJ, Harrison BL, Hoffmann EC, Kazdoba TM, Lewis MC, Quirk MC, Robichaud AJ. La DS, et al. Among authors: dai j. J Med Chem. 2019 Aug 22;62(16):7526-7542. doi: 10.1021/acs.jmedchem.9b00591. Epub 2019 Aug 13. J Med Chem. 2019. PMID: 31390523

5

Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.

Mannara F, Radosevic M, Planagumà J, Soto D, Aguilar E, García-Serra A, Maudes E, Pedreño M, Paul S, Doherty J, Quirk M, Dai J, Gasull X, Lewis M, Dalmau J. Mannara F, et al. Among authors: dai j. Brain. 2020 Sep 1;143(9):2709-2720. doi: 10.1093/brain/awaa195. Brain. 2020. PMID: 32830245

6

SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.

Hill MD, Blanco MJ, Salituro FG, Bai Z, Beckley JT, Ackley MA, Dai J, Doherty JJ, Harrison BL, Hoffmann EC, Kazdoba TM, Lanzetta D, Lewis M, Quirk MC, Robichaud AJ. Hill MD, et al. Among authors: dai j. J Med Chem. 2022 Jul 14;65(13):9063-9075. doi: 10.1021/acs.jmedchem.2c00313. Epub 2022 Jul 2. J Med Chem. 2022. PMID: 35785990

7

Pharmacological characterization of SAGE-718, a novel positive allosteric modulator of N-methyl-d-aspartate receptors.

Beckley JT, Aman TK, Ackley MA, Kazdoba TM, Lewis MC, Smith AC, Farley BJ, Dai J, Deats W, Hoffmann E, Robichaud AJ, Doherty JJ, Quirk MC. Beckley JT, et al. Among authors: dai j. Br J Pharmacol. 2024 Apr;181(7):1028-1050. doi: 10.1111/bph.16235. Epub 2023 Nov 13. Br J Pharmacol. 2024. PMID: 37698384

8

Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo.

Popiolek M, Izumi Y, Hopper AT, Dai J, Miller S, Shu HJ, Zorumski CF, Mennerick S. Popiolek M, et al. Among authors: dai j. Front Mol Neurosci. 2020 Oct 29;13:568641. doi: 10.3389/fnmol.2020.568641. eCollection 2020. Front Mol Neurosci. 2020. PMID: 33192294 Free PMC article.

9

Design and Application of Biosafe Coronavirus Engineering Systems without Virulence.

Wu G, Li Q, Dai J, Mao G, Ma Y. Wu G, et al. Among authors: dai j. Viruses. 2024 Apr 24;16(5):659. doi: 10.3390/v16050659. Viruses. 2024. PMID: 38793541 Review.

10

Design of a Compact 2-6 GHz High-Efficiency and High-Gain GaN Power Amplifier.

Zhou Y, Wang S, Dai J, Luo J, Cheng Q. Zhou Y, et al. Among authors: dai j. Micromachines (Basel). 2024 Apr 29;15(5):601. doi: 10.3390/mi15050601. Micromachines (Basel). 2024. PMID: 38793174

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