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SIRT1 is downregulated by autophagy in senescence and ageing.
Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL. Xu C, et al. Among authors: winkler jd. Nat Cell Biol. 2020 Oct;22(10):1170-1179. doi: 10.1038/s41556-020-00579-5. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989246 Free PMC article.
Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.
McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T, Sepulveda AR, Davis LE, Winkler JD, Amaravadi RK. McAfee Q, et al. Among authors: winkler jd. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8. doi: 10.1073/pnas.1118193109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566612 Free PMC article.
Lys05: a new lysosomal autophagy inhibitor.
Amaravadi RK, Winkler JD. Amaravadi RK, et al. Among authors: winkler jd. Autophagy. 2012 Sep;8(9):1383-4. doi: 10.4161/auto.20958. Epub 2012 Aug 10. Autophagy. 2012. PMID: 22878685 Free PMC article.
Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.
Hubbard-Lucey VM, Shono Y, Maurer K, West ML, Singer NV, Ziegler CG, Lezcano C, Motta AC, Schmid K, Levi SM, Murphy GF, Liu C, Winkler JD, Amaravadi RK, Rogler G, Dickinson AM, Holler E, van den Brink MR, Cadwell K. Hubbard-Lucey VM, et al. Among authors: winkler jd. Immunity. 2014 Oct 16;41(4):579-91. doi: 10.1016/j.immuni.2014.09.011. Epub 2014 Oct 9. Immunity. 2014. PMID: 25308334 Free PMC article.
Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma.
DeVorkin L, Hattersley M, Kim P, Ries J, Spowart J, Anglesio MS, Levi SM, Huntsman DG, Amaravadi RK, Winkler JD, Tinker AV, Lum JJ. DeVorkin L, et al. Among authors: winkler jd. Mol Cancer Res. 2017 Mar;15(3):250-258. doi: 10.1158/1541-7786.MCR-16-0132. Epub 2017 Feb 9. Mol Cancer Res. 2017. PMID: 28184014 Free PMC article.
Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma.
Gade TPF, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski GJ, Clark TWI, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC. Gade TPF, et al. Among authors: winkler jd. Radiology. 2017 Jun;283(3):702-710. doi: 10.1148/radiol.2017160728. Epub 2017 Mar 2. Radiology. 2017. PMID: 28253108 Free PMC article.
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.
Vijayaraghavan S, Karakas C, Doostan I, Chen X, Bui T, Yi M, Raghavendra AS, Zhao Y, Bashour SI, Ibrahim NK, Karuturi M, Wang J, Winkler JD, Amaravadi RK, Hunt KK, Tripathy D, Keyomarsi K. Vijayaraghavan S, et al. Among authors: winkler jd. Nat Commun. 2017 Jun 27;8:15916. doi: 10.1038/ncomms15916. Nat Commun. 2017. PMID: 28653662 Free PMC article.
ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.
Ndoye A, Budina-Kolomets A, Kugel CH 3rd, Webster MR, Kaur A, Behera R, Rebecca VW, Li L, Brafford PA, Liu Q, Gopal YNV, Davies MA, Mills GB, Xu X, Wu H, Herlyn M, Nicastri MC, Winkler JD, Soengas MS, Amaravadi RK, Murphy ME, Weeraratna AT. Ndoye A, et al. Among authors: winkler jd. Cancer Res. 2017 Nov 1;77(21):5873-5885. doi: 10.1158/0008-5472.CAN-17-0907. Epub 2017 Sep 8. Cancer Res. 2017. PMID: 28887323 Free PMC article.
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK. Rebecca VW, et al. Among authors: winkler jd. Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12. Cancer Discov. 2017. PMID: 28899863 Free PMC article.
169 results