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Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ1 Receptor Antagonist Clinical Candidate for the Treatment of Pain.
García M, Virgili M, Alonso M, Alegret C, Farran J, Fernández B, Bordas M, Pascual R, Burgueño J, Vidal-Torres A, Fernández de Henestrosa AR, Ayet E, Merlos M, Vela JM, Plata-Salamán CR, Almansa C. García M, et al. Among authors: ayet e. J Med Chem. 2020 Dec 24;63(24):15508-15526. doi: 10.1021/acs.jmedchem.0c01127. Epub 2020 Oct 16. J Med Chem. 2020. PMID: 33064947
Propionamide Derivatives as Dual μ-Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain.
García M, Llorente V, Garriga L, Christmann U, Rodríguez-Escrich S, Virgili M, Fernández B, Bordas M, Ayet E, Burgueño J, Pujol M, Dordal A, Portillo-Salido E, Gris G, Vela JM, Almansa C. García M, et al. Among authors: ayet e. J Med Chem. 2021 Jul 22;64(14):10139-10154. doi: 10.1021/acs.jmedchem.1c00417. Epub 2021 Jul 8. J Med Chem. 2021. PMID: 34236190
Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Vidal-Torres A, Fernández-Pastor B, García M, Ayet E, Cabot A, Burgueño J, Monroy X, Aubel B, Codony X, Romero L, Pascual R, Serafini MT, Encina G, Almansa C, Zamanillo D, Merlos M, Vela JM. Vidal-Torres A, et al. Among authors: ayet e. Acta Pharm Sin B. 2023 Jan;13(1):82-99. doi: 10.1016/j.apsb.2022.09.018. Epub 2022 Sep 25. Acta Pharm Sin B. 2023. PMID: 36815042 Free PMC article.
Oleoyl-estrone is a precursor of an estrone-derived ponderostat signal.
Vilà R, Cabot C, Villarreal L, Monegal A, Ayet E, Romero Mdel M, Grasa Mdel M, Esteve M, Fernández-López JA, Remesar X, Alemany M. Vilà R, et al. Among authors: ayet e. J Steroid Biochem Mol Biol. 2011 Apr;124(3-5):99-111. doi: 10.1016/j.jsbmb.2011.01.017. Epub 2011 Feb 12. J Steroid Biochem Mol Biol. 2011. PMID: 21310232