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Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ1 Receptor Antagonist Clinical Candidate for the Treatment of Pain.
García M, Virgili M, Alonso M, Alegret C, Farran J, Fernández B, Bordas M, Pascual R, Burgueño J, Vidal-Torres A, Fernández de Henestrosa AR, Ayet E, Merlos M, Vela JM, Plata-Salamán CR, Almansa C. García M, et al. Among authors: pascual r. J Med Chem. 2020 Dec 24;63(24):15508-15526. doi: 10.1021/acs.jmedchem.0c01127. Epub 2020 Oct 16. J Med Chem. 2020. PMID: 33064947
A medicinal-chemistry-guided approach to selective and druglike sigma 1 ligands.
Corbera J, Vaño D, Martínez D, Vela JM, Zamanillo D, Dordal A, Andreu F, Hernandez E, Perez R, Escriche M, Salgado L, Yeste S, Serafini MT, Pascual R, Alegre J, Calvet MC, Cano N, Carro M, Buschmann H, Holenz J. Corbera J, et al. Among authors: pascual r. ChemMedChem. 2006 Jan;1(1):140-54. doi: 10.1002/cmdc.200500034. ChemMedChem. 2006. PMID: 16892345
Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands.
Díaz JL, Christmann U, Fernández A, Luengo M, Bordas M, Enrech R, Carro M, Pascual R, Burgueño J, Merlos M, Benet-Buchholz J, Cerón-Bertran J, Ramírez J, Reinoso RF, Fernández de Henestrosa AR, Vela JM, Almansa C. Díaz JL, et al. Among authors: pascual r. J Med Chem. 2013 May 9;56(9):3656-65. doi: 10.1021/jm400181k. Epub 2013 Apr 26. J Med Chem. 2013. PMID: 23560650
4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain.
García M, Virgili M, Alonso M, Alegret C, Fernández B, Port A, Pascual R, Monroy X, Vidal-Torres A, Serafini MT, Vela JM, Almansa C. García M, et al. Among authors: pascual r. J Med Chem. 2020 Mar 12;63(5):2434-2454. doi: 10.1021/acs.jmedchem.9b01256. Epub 2019 Dec 5. J Med Chem. 2020. PMID: 31743642 Free article.
Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter.
Díaz JL, Cuevas F, Pazos G, Álvarez-Bercedo P, Oliva AI, Sarmentero MÁ, Font D, Jiménez-Aquino A, Morón M, Port A, Pascual R, Dordal A, Portillo-Salido E, Reinoso RF, Vela JM, Almansa C. Díaz JL, et al. Among authors: pascual r. J Med Chem. 2021 Feb 25;64(4):2167-2185. doi: 10.1021/acs.jmedchem.0c01867. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33591743
276 results