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Association of 1-deoxy-sphingolipids with steatosis but not steatohepatitis nor fibrosis in non-alcoholic fatty liver disease.
Weyler J, Verrijken A, Hornemann T, Vonghia L, Dirinck E, von Eckardstein A, Vanwolleghem T, Michielsen P, Peiffer F, Driessen A, Hubens G, Staels B, Francque S, Van Gaal L. Weyler J, et al. Among authors: staels b. Acta Diabetol. 2021 Mar;58(3):319-327. doi: 10.1007/s00592-020-01612-7. Epub 2020 Oct 21. Acta Diabetol. 2021. PMID: 33084982
Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia.
Caron S, Verrijken A, Mertens I, Samanez CH, Mautino G, Haas JT, Duran-Sandoval D, Prawitt J, Francque S, Vallez E, Muhr-Tailleux A, Berard I, Kuipers F, Kuivenhoven JA, Biddinger SB, Taskinen MR, Van Gaal L, Staels B. Caron S, et al. Among authors: staels b. Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):513-9. doi: 10.1161/ATVBAHA.110.220723. Epub 2010 Dec 23. Arterioscler Thromb Vasc Biol. 2011. PMID: 21183731
LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.
Bieghs V, Van Gorp PJ, Wouters K, Hendrikx T, Gijbels MJ, van Bilsen M, Bakker J, Binder CJ, Lütjohann D, Staels B, Hofker MH, Shiri-Sverdlov R. Bieghs V, et al. Among authors: staels b. PLoS One. 2012;7(1):e30668. doi: 10.1371/journal.pone.0030668. Epub 2012 Jan 25. PLoS One. 2012. PMID: 22295101 Free PMC article.
A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.
Verrijken A, Beckers S, Francque S, Hilden H, Caron S, Zegers D, Ruppert M, Hubens G, Van Marck E, Michielsen P, Staels B, Taskinen MR, Van Hul W, Van Gaal L. Verrijken A, et al. Among authors: staels b. Obesity (Silver Spring). 2013 Oct;21(10):2138-45. doi: 10.1002/oby.20366. Epub 2013 Jun 6. Obesity (Silver Spring). 2013. PMID: 23512881 Free article.
Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ, Baron M, Lucas A, Tailleux A, Hum DW, Ratziu V, Cariou B, Hanf R. Staels B, et al. Hepatology. 2013 Dec;58(6):1941-52. doi: 10.1002/hep.26461. Epub 2013 Oct 29. Hepatology. 2013. PMID: 23703580 Clinical Trial.
SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus.
Hassing HC, Surendran RP, Derudas B, Verrijken A, Francque SM, Mooij HL, Bernelot Moens SJ, Hart LM, Nijpels G, Dekker JM, Williams KJ, Stroes ES, Van Gaal LF, Staels B, Nieuwdorp M, Dallinga-Thie GM. Hassing HC, et al. Among authors: staels b. Obesity (Silver Spring). 2014 May;22(5):1309-16. doi: 10.1002/oby.20682. Epub 2014 Jan 9. Obesity (Silver Spring). 2014. PMID: 24339435 Free PMC article.
PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis.
Francque S, Verrijken A, Caron S, Prawitt J, Paumelle R, Derudas B, Lefebvre P, Taskinen MR, Van Hul W, Mertens I, Hubens G, Van Marck E, Michielsen P, Van Gaal L, Staels B. Francque S, et al. Among authors: staels b. J Hepatol. 2015 Jul;63(1):164-73. doi: 10.1016/j.jhep.2015.02.019. Epub 2015 Feb 19. J Hepatol. 2015. PMID: 25703085
795 results