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Itaconate controls the severity of pulmonary fibrosis.
Ogger PP, Albers GJ, Hewitt RJ, O'Sullivan BJ, Powell JE, Calamita E, Ghai P, Walker SA, McErlean P, Saunders P, Kingston S, Molyneaux PL, Halket JM, Gray R, Chambers DC, Maher TM, Lloyd CM, Byrne AJ. Ogger PP, et al. Among authors: byrne aj. Sci Immunol. 2020 Oct 23;5(52):eabc1884. doi: 10.1126/sciimmunol.abc1884. Sci Immunol. 2020. PMID: 33097591 Free PMC article.
A critical role for IRF5 in regulating allergic airway inflammation.
Byrne AJ, Weiss M, Mathie SA, Walker SA, Eames HL, Saliba D, Lloyd CM, Udalova IA. Byrne AJ, et al. Mucosal Immunol. 2017 May;10(3):716-726. doi: 10.1038/mi.2016.92. Epub 2016 Oct 19. Mucosal Immunol. 2017. PMID: 27759022 Free PMC article.
Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.
Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM. Saglani S, et al. Sci Immunol. 2018 Sep 7;3(27):eaan4128. doi: 10.1126/sciimmunol.aan4128. Sci Immunol. 2018. PMID: 30194239 Free PMC article.
The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis.
Allden SJ, Ogger PP, Ghai P, McErlean P, Hewitt R, Toshner R, Walker SA, Saunders P, Kingston S, Molyneaux PL, Maher TM, Lloyd CM, Byrne AJ. Allden SJ, et al. Among authors: byrne aj. Am J Respir Crit Care Med. 2019 Jul 15;200(2):209-219. doi: 10.1164/rccm.201809-1775OC. Am J Respir Crit Care Med. 2019. PMID: 31051082 Free PMC article.
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.
Ng B, Dong J, D'Agostino G, Viswanathan S, Widjaja AA, Lim WW, Ko NSJ, Tan J, Chothani SP, Huang B, Xie C, Pua CJ, Chacko AM, Guimarães-Camboa N, Evans SM, Byrne AJ, Maher TM, Liang J, Jiang D, Noble PW, Schafer S, Cook SA. Ng B, et al. Among authors: byrne aj. Sci Transl Med. 2019 Sep 25;11(511):eaaw1237. doi: 10.1126/scitranslmed.aaw1237. Sci Transl Med. 2019. PMID: 31554736
138 results