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Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.
Custódio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hällberg BM, Löw C. Custódio TF, et al. Among authors: seeger ma. Nat Commun. 2020 Nov 4;11(1):5588. doi: 10.1038/s41467-020-19204-y. Nat Commun. 2020. PMID: 33149112 Free PMC article.
Generation of synthetic nanobodies against delicate proteins.
Zimmermann I, Egloff P, Hutter CAJ, Kuhn BT, Bräuer P, Newstead S, Dawson RJP, Geertsma ER, Seeger MA. Zimmermann I, et al. Among authors: seeger ma. Nat Protoc. 2020 May;15(5):1707-1741. doi: 10.1038/s41596-020-0304-x. Epub 2020 Apr 8. Nat Protoc. 2020. PMID: 32269381
Structural insights into the inhibition of glycine reuptake.
Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR, Dawson RJP, Nissen P. Shahsavar A, et al. Among authors: seeger ma. Nature. 2021 Mar;591(7851):677-681. doi: 10.1038/s41586-021-03274-z. Epub 2021 Mar 3. Nature. 2021. PMID: 33658720
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.
Li T, Cai H, Yao H, Zhou B, Zhang N, van Vlissingen MF, Kuiken T, Han W, GeurtsvanKessel CH, Gong Y, Zhao Y, Shen Q, Qin W, Tian XX, Peng C, Lai Y, Wang Y, Hutter CAJ, Kuo SM, Bao J, Liu C, Wang Y, Richard AS, Raoul H, Lan J, Seeger MA, Cong Y, Rockx B, Wong G, Bi Y, Lavillette D, Li D. Li T, et al. Among authors: seeger ma. Nat Commun. 2021 Jul 30;12(1):4635. doi: 10.1038/s41467-021-24905-z. Nat Commun. 2021. PMID: 34330908 Free PMC article.
Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Walter JD, Scherer M, Hutter CAJ, Garaeva AA, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Hürlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, van Geest G, Bruggmann R, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA. Walter JD, et al. Among authors: seeger ma. EMBO Rep. 2022 Apr 5;23(4):e54199. doi: 10.15252/embr.202154199. Epub 2022 Mar 7. EMBO Rep. 2022. PMID: 35253970 Free PMC article.
Biomolecules capturing live bacteria from clinical samples.
Sorgenfrei M, Hürlimann LM, Remy MM, Keller PM, Seeger MA. Sorgenfrei M, et al. Among authors: seeger ma. Trends Biochem Sci. 2022 Aug;47(8):673-688. doi: 10.1016/j.tibs.2022.03.018. Epub 2022 Apr 27. Trends Biochem Sci. 2022. PMID: 35487808 Review.
Author Correction: A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.
Li T, Cai H, Yao H, Zhou B, Zhang N, van Vlissingen MF, Kuiken T, Han W, GeurtsvanKessel CH, Gong Y, Zhao Y, Shen Q, Qin W, Tian XX, Peng C, Lai Y, Wang Y, Hutter CAJ, Kuo SM, Bao J, Liu C, Wang Y, Richard AS, Raoul H, Lan J, Seeger MA, Cong Y, Rockx B, Wong G, Bi Y, Lavillette D, Li D. Li T, et al. Among authors: seeger ma. Nat Commun. 2022 Jul 27;13(1):4359. doi: 10.1038/s41467-022-32074-w. Nat Commun. 2022. PMID: 35896553 Free PMC article. No abstract available.
114 results