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Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.
Nat Commun. 2020 Nov 4;11(1):5566. doi: 10.1038/s41467-020-19412-6.
Nat Commun. 2020.
PMID: 33149141
Free PMC article.
Experimental study of tuberculosis: From animal models to complex cell systems and organoids.
Fonseca KL, Rodrigues PNS, Olsson IAS, Saraiva M.
Fonseca KL, et al.
PLoS Pathog. 2017 Aug 17;13(8):e1006421. doi: 10.1371/journal.ppat.1006421. eCollection 2017 Aug.
PLoS Pathog. 2017.
PMID: 28817682
Free PMC article.
Review.
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Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum.
Cá B, Fonseca KL, Sousa J, Maceiras AR, Machado D, Sanca L, Rabna P, Rodrigues PNS, Viveiros M, Saraiva M.
Cá B, et al. Among authors: fonseca kl.
Front Microbiol. 2019 Sep 10;10:2102. doi: 10.3389/fmicb.2019.02102. eCollection 2019.
Front Microbiol. 2019.
PMID: 31552007
Free PMC article.
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Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils.
Fonseca KL, Maceiras AR, Matos R, Simoes-Costa L, Sousa J, Cá B, Barros L, Fernandes AI, Mereiter S, Reis R, Gomes J, Tapia G, Rodríguez-Martínez P, Martín-Céspedes M, Vashakidze S, Gogishvili S, Nikolaishvili K, Appelberg R, Gärtner F, Rodrigues PNS, Vilaplana C, Reis CA, Magalhães A, Saraiva M.
Fonseca KL, et al.
Mucosal Immunol. 2020 Sep;13(5):836-848. doi: 10.1038/s41385-020-0277-7. Epub 2020 Mar 13.
Mucosal Immunol. 2020.
PMID: 32203062
Free PMC article.
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Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.
Moreira-Teixeira L, Tabone O, Graham CM, Singhania A, Stavropoulos E, Redford PS, Chakravarty P, Priestnall SL, Suarez-Bonnet A, Herbert E, Mayer-Barber KD, Sher A, Fonseca KL, Sousa J, Cá B, Verma R, Haldar P, Saraiva M, O'Garra A.
Moreira-Teixeira L, et al. Among authors: fonseca kl.
Nat Immunol. 2020 Apr;21(4):464-476. doi: 10.1038/s41590-020-0610-z. Epub 2020 Mar 16.
Nat Immunol. 2020.
PMID: 32205882
Free PMC article.
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Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production.
Sousa J, Cá B, Maceiras AR, Simões-Costa L, Fonseca KL, Fernandes AI, Ramos A, Carvalho T, Barros L, Magalhães C, Chiner-Oms Á, Machado H, Veiga MI, Singh A, Pereira R, Amorim A, Vieira J, Vieira CP, Bhatt A, Rodrigues F, Rodrigues PNS, Gagneux S, Castro AG, Guimarães JT, Bastos HN, Osório NS, Comas I, Saraiva M.
Sousa J, et al. Among authors: fonseca kl.
Nat Commun. 2020 Apr 23;11(1):1949. doi: 10.1038/s41467-020-15832-6.
Nat Commun. 2020.
PMID: 32327653
Free PMC article.
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Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium.
Matos R, Fonseca KL, Mereiter S, Maceiras AR, Gomes J, Vilaplana C, Gartner F, Rodrigues PNS, Reis CA, Saraiva M, Magalhães A.
Matos R, et al. Among authors: fonseca kl.
Microorganisms. 2021 Jan 4;9(1):99. doi: 10.3390/microorganisms9010099.
Microorganisms. 2021.
PMID: 33406734
Free PMC article.
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SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen.
Arias L, Otwombe K, Waja Z, Tukvadze N, Korinteli T, Moloantoa T, Fonseca KL, Pillay N, Seiphetlo T, Ouchi-Vernet D, Siles A, Carabias L, Quiñones C, Vashakidze S, Martinson N, Vilaplana C.
Arias L, et al. Among authors: fonseca kl.
Trials. 2023 Jun 28;24(1):435. doi: 10.1186/s13063-023-07448-0.
Trials. 2023.
PMID: 37370174
Free PMC article.
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