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Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.
Moreira-Teixeira L, Stimpson PJ, Stavropoulos E, Hadebe S, Chakravarty P, Ioannou M, Aramburu IV, Herbert E, Priestnall SL, Suarez-Bonnet A, Sousa J, Fonseca KL, Wang Q, Vashakidze S, Rodríguez-Martínez P, Vilaplana C, Saraiva M, Papayannopoulos V, O'Garra A. Moreira-Teixeira L, et al. Among authors: vashakidze s. Nat Commun. 2020 Nov 4;11(1):5566. doi: 10.1038/s41467-020-19412-6. Nat Commun. 2020. PMID: 33149141 Free PMC article.
Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils.
Fonseca KL, Maceiras AR, Matos R, Simoes-Costa L, Sousa J, Cá B, Barros L, Fernandes AI, Mereiter S, Reis R, Gomes J, Tapia G, Rodríguez-Martínez P, Martín-Céspedes M, Vashakidze S, Gogishvili S, Nikolaishvili K, Appelberg R, Gärtner F, Rodrigues PNS, Vilaplana C, Reis CA, Magalhães A, Saraiva M. Fonseca KL, et al. Among authors: vashakidze s. Mucosal Immunol. 2020 Sep;13(5):836-848. doi: 10.1038/s41385-020-0277-7. Epub 2020 Mar 13. Mucosal Immunol. 2020. PMID: 32203062 Free PMC article.
Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections.
Moreno-Molina M, Shubladze N, Khurtsilava I, Avaliani Z, Bablishvili N, Torres-Puente M, Villamayor L, Gabrielian A, Rosenthal A, Vilaplana C, Gagneux S, Kempker RR, Vashakidze S, Comas I. Moreno-Molina M, et al. Among authors: vashakidze s. Nat Commun. 2021 May 11;12(1):2716. doi: 10.1038/s41467-021-22705-z. Nat Commun. 2021. PMID: 33976135 Free PMC article.
SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen.
Arias L, Otwombe K, Waja Z, Tukvadze N, Korinteli T, Moloantoa T, Fonseca KL, Pillay N, Seiphetlo T, Ouchi-Vernet D, Siles A, Carabias L, Quiñones C, Vashakidze S, Martinson N, Vilaplana C. Arias L, et al. Among authors: vashakidze s. Trials. 2023 Jun 28;24(1):435. doi: 10.1186/s13063-023-07448-0. Trials. 2023. PMID: 37370174 Free PMC article.
Additional drug resistance in Mycobacterium tuberculosis isolates from resected cavities among patients with multidrug-resistant or extensively drug-resistant pulmonary tuberculosis.
Kempker RR, Rabin AS, Nikolaishvili K, Kalandadze I, Gogishvili S, Blumberg HM, Vashakidze S. Kempker RR, et al. Among authors: vashakidze s. Clin Infect Dis. 2012 Mar;54(6):e51-4. doi: 10.1093/cid/cir904. Epub 2011 Dec 23. Clin Infect Dis. 2012. PMID: 22198790 Free PMC article.
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