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CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14.
Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari J, Pang APS, Sugai C, Mahyari E, Francisco EB, Pise A, Rodrigues H, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Bimber BN, Plassmeyer M, Gupta R, Alpan O, O'Halloran JA, Mudd PA, Akalin E, Ndhlovu LC, Sacha JB. Patterson BK, et al. Int J Infect Dis. 2021 Feb;103:25-32. doi: 10.1016/j.ijid.2020.10.101. Epub 2020 Nov 10. Int J Infect Dis. 2021. PMID: 33186704 Free PMC article.
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm.
Mudd PA, Crawford JC, Turner JS, Souquette A, Reynolds D, Bender D, Bosanquet JP, Anand NJ, Striker DA, Martin RS, Boon ACM, House SL, Remy KE, Hotchkiss RS, Presti RM, O'Halloran JA, Powderly WG, Thomas PG, Ellebedy AH. Mudd PA, et al. Sci Adv. 2020 Dec 9;6(50):eabe3024. doi: 10.1126/sciadv.abe3024. Print 2020 Dec. Sci Adv. 2020. PMID: 33187979 Free PMC article.
Interleukin-6 Trajectory and Secondary Infections in Mechanically Ventilated Patients With Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Treated With Interleukin-6 Receptor Blocker.
Vazquez Guillamet MC, Kulkarni HS, Montes K, Samant M, Shaikh PA, Betthauser K, Mudd PA, Reynolds D, O'Halloran J, Lyons P, McEvoy C, Vazquez Guillamet R. Vazquez Guillamet MC, et al. Crit Care Explor. 2021 Feb 3;3(2):e0343. doi: 10.1097/CCE.0000000000000343. eCollection 2021 Feb. Crit Care Explor. 2021. PMID: 33554125 Free PMC article.
Asthma in patients with suspected and diagnosed coronavirus disease 2019.
Cao L, Lee S, Krings JG, Rauseo AM, Reynolds D, Presti R, Goss C, Mudd PA, O'Halloran JA, Wang L. Cao L, et al. Ann Allergy Asthma Immunol. 2021 May;126(5):535-541.e2. doi: 10.1016/j.anai.2021.02.020. Epub 2021 Feb 25. Ann Allergy Asthma Immunol. 2021. PMID: 33639262 Free PMC article.
Comprehensive Immunologic Evaluation of Bronchoalveolar Lavage Samples from Human Patients with Moderate and Severe Seasonal Influenza and Severe COVID-19.
Reynolds D, Vazquez Guillamet C, Day A, Borcherding N, Vazquez Guillamet R, Choreño-Parra JA, House SL, O'Halloran JA, Zúñiga J, Ellebedy AH, Byers DE, Mudd PA. Reynolds D, et al. J Immunol. 2021 Sep 1;207(5):1229-1238. doi: 10.4049/jimmunol.2100294. Epub 2021 Aug 4. J Immunol. 2021. PMID: 34348975 Free PMC article.
Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination.
Kim W, Zhou JQ, Sturtz AJ, Horvath SC, Schmitz AJ, Lei T, Kalaidina E, Thapa M, Alsoussi WB, Haile A, Klebert MK, Suessen T, Parra-Rodriguez L, Mudd PA, Middleton WD, Teefey SA, Pusic I, O'Halloran JA, Presti RM, Turner JS, Ellebedy AH. Kim W, et al. bioRxiv [Preprint]. 2021 Nov 2:2021.10.31.466651. doi: 10.1101/2021.10.31.466651. bioRxiv. 2021. PMID: 34751268 Free PMC article. Updated. Preprint.
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans.
Mudd PA, Minervina AA, Pogorelyy MV, Turner JS, Kim W, Kalaidina E, Petersen J, Schmitz AJ, Lei T, Haile A, Kirk AM, Mettelman RC, Crawford JC, Nguyen THO, Rowntree LC, Rosati E, Richards KA, Sant AJ, Klebert MK, Suessen T, Middleton WD; SJTRC Study Team; Wolf J, Teefey SA, O'Halloran JA, Presti RM, Kedzierska K, Rossjohn J, Thomas PG, Ellebedy AH. Mudd PA, et al. Cell. 2022 Feb 17;185(4):603-613.e15. doi: 10.1016/j.cell.2021.12.026. Epub 2021 Dec 23. Cell. 2022. PMID: 35026152 Free PMC article.
99 results