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JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.
Stebbing J, Sánchez Nievas G, Falcone M, Youhanna S, Richardson P, Ottaviani S, Shen JX, Sommerauer C, Tiseo G, Ghiadoni L, Virdis A, Monzani F, Rizos LR, Forfori F, Avendaño Céspedes A, De Marco S, Carrozzi L, Lena F, Sánchez-Jurado PM, Lacerenza LG, Cesira N, Caldevilla Bernardo D, Perrella A, Niccoli L, Méndez LS, Matarrese D, Goletti D, Tan YJ, Monteil V, Dranitsaris G, Cantini F, Farcomeni A, Dutta S, Burley SK, Zhang H, Pistello M, Li W, Romero MM, Andrés Pretel F, Simón-Talero RS, García-Molina R, Kutter C, Felce JH, Nizami ZF, Miklosi AG, Penninger JM, Menichetti F, Mirazimi A, Abizanda P, Lauschke VM. Stebbing J, et al. Among authors: shen jx. Sci Adv. 2021 Jan 1;7(1):eabe4724. doi: 10.1126/sciadv.abe4724. Print 2021 Jan. Sci Adv. 2021. PMID: 33187978 Free PMC article.
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
Azzimato V, Jager J, Chen P, Morgantini C, Levi L, Barreby E, Sulen A, Oses C, Willerbrords J, Xu C, Li X, Shen JX, Akbar N, Haag L, Ellis E, Wålhen K, Näslund E, Thorell A, Choudhury RP, Lauschke VM, Rydén M, Craige SM, Aouadi M. Azzimato V, et al. Among authors: shen jx. Sci Transl Med. 2020 Feb 26;12(532):eaaw9709. doi: 10.1126/scitranslmed.aaw9709. Sci Transl Med. 2020. PMID: 32102936
Bioengineered Pancreas-Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia.
Zandi Shafagh R, Youhanna S, Keulen J, Shen JX, Taebnia N, Preiss LC, Klein K, Büttner FA, Bergqvist M, van der Wijngaart W, Lauschke VM. Zandi Shafagh R, et al. Among authors: shen jx. Adv Sci (Weinh). 2022 Dec;9(34):e2203368. doi: 10.1002/advs.202203368. Epub 2022 Oct 26. Adv Sci (Weinh). 2022. PMID: 36285680 Free PMC article.
Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
Sommerauer C, Gallardo-Dodd CJ, Savva C, Hases L, Birgersson M, Indukuri R, Shen JX, Carravilla P, Geng K, Nørskov Søndergaard J, Ferrer-Aumatell C, Mercier G, Sezgin E, Korach-André M, Petersson C, Hagström H, Lauschke VM, Archer A, Williams C, Kutter C. Sommerauer C, et al. Among authors: shen jx. Mol Syst Biol. 2024 Apr;20(4):374-402. doi: 10.1038/s44320-024-00024-x. Epub 2024 Mar 8. Mol Syst Biol. 2024. PMID: 38459198 Free PMC article.
In vitro and ex vivo models of adipocytes.
Dufau J, Shen JX, Couchet M, De Castro Barbosa T, Mejhert N, Massier L, Griseti E, Mouisel E, Amri EZ, Lauschke VM, Rydén M, Langin D. Dufau J, et al. Among authors: shen jx. Am J Physiol Cell Physiol. 2021 May 1;320(5):C822-C841. doi: 10.1152/ajpcell.00519.2020. Epub 2021 Jan 13. Am J Physiol Cell Physiol. 2021. PMID: 33439778 Free article. Review.
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis.
Shen JX, Couchet M, Dufau J, de Castro Barbosa T, Ulbrich MH, Helmstädter M, Kemas AM, Zandi Shafagh R, Marques MA, Hansen JB, Mejhert N, Langin D, Rydén M, Lauschke VM. Shen JX, et al. Adv Sci (Weinh). 2021 Aug;8(16):e2100106. doi: 10.1002/advs.202100106. Epub 2021 Jun 24. Adv Sci (Weinh). 2021. PMID: 34165908 Free PMC article.
284 results