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JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.
Stebbing J, Sánchez Nievas G, Falcone M, Youhanna S, Richardson P, Ottaviani S, Shen JX, Sommerauer C, Tiseo G, Ghiadoni L, Virdis A, Monzani F, Rizos LR, Forfori F, Avendaño Céspedes A, De Marco S, Carrozzi L, Lena F, Sánchez-Jurado PM, Lacerenza LG, Cesira N, Caldevilla Bernardo D, Perrella A, Niccoli L, Méndez LS, Matarrese D, Goletti D, Tan YJ, Monteil V, Dranitsaris G, Cantini F, Farcomeni A, Dutta S, Burley SK, Zhang H, Pistello M, Li W, Romero MM, Andrés Pretel F, Simón-Talero RS, García-Molina R, Kutter C, Felce JH, Nizami ZF, Miklosi AG, Penninger JM, Menichetti F, Mirazimi A, Abizanda P, Lauschke VM. Stebbing J, et al. Among authors: zhang h. Sci Adv. 2021 Jan 1;7(1):eabe4724. doi: 10.1126/sciadv.abe4724. Print 2021 Jan. Sci Adv. 2021. PMID: 33187978 Free PMC article.
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Hurtado Del Pozo C, Prosper F, Romero JP, Wirnsberger G, Zhang H, Slutsky AS, Conder R, Montserrat N, Mirazimi A, Penninger JM. Monteil V, et al. Among authors: zhang h. Cell. 2020 May 14;181(4):905-913.e7. doi: 10.1016/j.cell.2020.04.004. Epub 2020 Apr 24. Cell. 2020. PMID: 32333836 Free PMC article.
Human recombinant soluble ACE2 in severe COVID-19.
Zoufaly A, Poglitsch M, Aberle JH, Hoepler W, Seitz T, Traugott M, Grieb A, Pawelka E, Laferl H, Wenisch C, Neuhold S, Haider D, Stiasny K, Bergthaler A, Puchhammer-Stoeckl E, Mirazimi A, Montserrat N, Zhang H, Slutsky AS, Penninger JM. Zoufaly A, et al. Among authors: zhang h. Lancet Respir Med. 2020 Nov;8(11):1154-1158. doi: 10.1016/S2213-2600(20)30418-5. Epub 2020 Sep 24. Lancet Respir Med. 2020. PMID: 33131609 Free PMC article. No abstract available.
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.
Monteil V, Dyczynski M, Lauschke VM, Kwon H, Wirnsberger G, Youhanna S, Zhang H, Slutsky AS, Hurtado Del Pozo C, Horn M, Montserrat N, Penninger JM, Mirazimi A. Monteil V, et al. Among authors: zhang h. EMBO Mol Med. 2021 Jan 11;13(1):e13426. doi: 10.15252/emmm.202013426. Epub 2020 Dec 14. EMBO Mol Med. 2021. PMID: 33179852 Free PMC article.
SARS-CoV-2 virus-like-particles via liposomal reconstitution of spike glycoproteins.
McColman S, Shkalla K, Sidhu P, Liang J, Osman S, Kovacs N, Bokhari Z, Forjaz Marques AC, Li Y, Lin Q, Zhang H, Cramb DT. McColman S, et al. Among authors: zhang h. Nanoscale Adv. 2023 Jul 14;5(16):4167-4181. doi: 10.1039/d3na00190c. eCollection 2023 Aug 8. Nanoscale Adv. 2023. PMID: 37560413 Free PMC article.
The Tie2-agonist Vasculotide rescues mice from influenza virus infection.
Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani S, Zhang H, Szaszi K, Tabuchi A, Kuebler WM, Van Slyke P, Dumont DJ, Lee WL. Sugiyama MG, et al. Among authors: zhang h. Sci Rep. 2015 Jun 5;5:11030. doi: 10.1038/srep11030. Sci Rep. 2015. PMID: 26046800 Free PMC article.
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