Leffler H - Search Results

1

Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.

Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM. Hirani N, et al. Among authors: leffler h. Eur Respir J. 2021 May 27;57(5):2002559. doi: 10.1183/13993003.02559-2020. Print 2021 May. Eur Respir J. 2021. PMID: 33214209 Free PMC article. Clinical Trial.

2

Low micromolar inhibitors of galectin-3 based on 3'-derivatization of N-acetyllactosamine.

Sörme P, Qian Y, Nyholm PG, Leffler H, Nilsson UJ. Sörme P, et al. Among authors: leffler h. Chembiochem. 2002 Mar 1;3(2-3):183-9. doi: 10.1002/1439-7633(20020301)3:2/3<183::aid-cbic183>3.0.co;2-#. Chembiochem. 2002. PMID: 11921396

3

Fluorescence polarization to study galectin-ligand interactions.

Sörme P, Kahl-Knutson B, Wellmar U, Nilsson UJ, Leffler H. Sörme P, et al. Among authors: leffler h. Methods Enzymol. 2003;362:504-12. doi: 10.1016/S0076-6879(03)01033-4. Methods Enzymol. 2003. PMID: 12968384 No abstract available.

4

Design and synthesis of galectin inhibitors.

Sörme P, Kahl-Knutsson B, Wellmar U, Magnusson BG, Leffler H, Nilsson UJ. Sörme P, et al. Among authors: leffler h. Methods Enzymol. 2003;363:157-69. doi: 10.1016/S0076-6879(03)01050-4. Methods Enzymol. 2003. PMID: 14579574 No abstract available.

5

Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions.

Sörme P, Kahl-Knutsson B, Huflejt M, Nilsson UJ, Leffler H. Sörme P, et al. Among authors: leffler h. Anal Biochem. 2004 Nov 1;334(1):36-47. doi: 10.1016/j.ab.2004.06.042. Anal Biochem. 2004. PMID: 15464951

6

Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.

Sörme P, Arnoux P, Kahl-Knutsson B, Leffler H, Rini JM, Nilsson UJ. Sörme P, et al. Among authors: leffler h. J Am Chem Soc. 2005 Feb 16;127(6):1737-43. doi: 10.1021/ja043475p. J Am Chem Soc. 2005. PMID: 15701008

7

Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors.

Tejler J, Leffler H, Nilsson UJ. Tejler J, et al. Among authors: leffler h. Bioorg Med Chem Lett. 2005 May 2;15(9):2343-5. doi: 10.1016/j.bmcl.2005.02.079. Bioorg Med Chem Lett. 2005. PMID: 15837322 Free article.

8

Synthesis of a phenyl thio-beta-D-galactopyranoside library from 1,5-difluoro-2,4-dinitrobenzene: discovery of efficient and selective monosaccharide inhibitors of galectin-7.

Cumpstey I, Carlsson S, Leffler H, Nilsson UJ. Cumpstey I, et al. Among authors: leffler h. Org Biomol Chem. 2005 May 21;3(10):1922-32. doi: 10.1039/b502354h. Epub 2005 Apr 14. Org Biomol Chem. 2005. PMID: 15889175

9

3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3.

Salameh BA, Leffler H, Nilsson UJ. Salameh BA, et al. Among authors: leffler h. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3344-6. doi: 10.1016/j.bmcl.2005.05.084. Bioorg Med Chem Lett. 2005. PMID: 15963723

10

C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions.

Cumpstey I, Sundin A, Leffler H, Nilsson UJ. Cumpstey I, et al. Among authors: leffler h. Angew Chem Int Ed Engl. 2005 Aug 12;44(32):5110-2. doi: 10.1002/anie.200500627. Angew Chem Int Ed Engl. 2005. PMID: 16007713 No abstract available.

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