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Melanoma cells can be eliminated by sialylated CD43 × CD3 bispecific T cell engager formats in vitro and in vivo.
de Jong G, Bartels L, Kedde M, Verdegaal EME, Gillissen MA, Levie SE, Cercel MG, van Hal-van Veen SE, Fatmawati C, van de Berg D, Yasuda E, Claassen YB, Bakker AQ, van der Burg SH, Schotte R, Villaudy J, Spits H, Hazenberg MD, van Helden PM, Wagner K. de Jong G, et al. Among authors: bakker aq. Cancer Immunol Immunother. 2021 Jun;70(6):1569-1581. doi: 10.1007/s00262-020-02780-9. Epub 2020 Nov 23. Cancer Immunol Immunother. 2021. PMID: 33225419 Free PMC article.
A Chemo-enzymatically Linked Bispecific Antibody Retargets T Cells to a Sialylated Epitope on CD43 in Acute Myeloid Leukemia.
Bartels L, de Jong G, Gillissen MA, Yasuda E, Kattler V, Bru C, Fatmawati C, van Hal-van Veen SE, Cercel MG, Moiset G, Bakker AQ, van Helden PM, Villaudy J, Hazenberg MD, Spits H, Wagner K. Bartels L, et al. Among authors: bakker aq. Cancer Res. 2019 Jul 1;79(13):3372-3382. doi: 10.1158/0008-5472.CAN-18-0189. Epub 2019 May 7. Cancer Res. 2019. PMID: 31064847
AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses.
Gillissen MA, Kedde M, Jong G, Moiset G, Yasuda E, Levie SE, Bakker AQ, Claassen YB, Wagner K, Böhne M, Hensbergen PJ, Speijer D, van Helden PM, Beaumont T, Spits H, Hazenberg MD. Gillissen MA, et al. Among authors: bakker aq. Blood. 2018 Jan 4;131(1):131-143. doi: 10.1182/blood-2017-02-768762. Epub 2017 Oct 23. Blood. 2018. PMID: 29061569 Free article.
Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice.
Gillissen MA, de Jong G, Kedde M, Yasuda E, Levie SE, Moiset G, Hensbergen PJ, Bakker AQ, Wagner K, Villaudy J, van Helden PM, Spits H, Hazenberg MD. Gillissen MA, et al. Among authors: bakker aq. Blood Adv. 2017 Aug 18;1(19):1551-1564. doi: 10.1182/bloodadvances.2017008342. eCollection 2017 Aug 22. Blood Adv. 2017. PMID: 29296797 Free PMC article.
AML relapse after rituximab treatment for GvHD: crucial role for B cells in GvL responses.
Gillissen MA, de Jong G, Levie SE, Yasuda E, Bakker AQ, Evers LM, Pals ST, Huisman C, van Helden PM, Spits H, Hazenberg MD. Gillissen MA, et al. Among authors: bakker aq. Bone Marrow Transplant. 2016 Sep;51(9):1245-8. doi: 10.1038/bmt.2016.90. Epub 2016 Apr 18. Bone Marrow Transplant. 2016. PMID: 27088384 No abstract available.
Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity.
Wagner K, Kwakkenbos MJ, Claassen YB, Maijoor K, Böhne M, van der Sluijs KF, Witte MD, van Zoelen DJ, Cornelissen LA, Beaumont T, Bakker AQ, Ploegh HL, Spits H. Wagner K, et al. Among authors: bakker aq. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16820-5. doi: 10.1073/pnas.1408605111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385586 Free PMC article.
Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance.
Merat SJ, Molenkamp R, Wagner K, Koekkoek SM, van de Berg D, Yasuda E, Böhne M, Claassen YB, Grady BP, Prins M, Bakker AQ, de Jong MD, Spits H, Schinkel J, Beaumont T. Merat SJ, et al. Among authors: bakker aq. PLoS One. 2016 Oct 24;11(10):e0165047. doi: 10.1371/journal.pone.0165047. eCollection 2016. PLoS One. 2016. PMID: 27776169 Free PMC article.
44 results