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A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.
Enriquez-Hesles E, Smith DL Jr, Maqani N, Wierman MB, Sutcliffe MD, Fine RD, Kalita A, Santos SM, Muehlbauer MJ, Bain JR, Janes KA, Hartman JL 4th, Hirschey MD, Smith JS. Enriquez-Hesles E, et al. Among authors: hirschey md. J Biol Chem. 2021 Jan-Jun;296:100125. doi: 10.1074/jbc.RA120.015402. Epub 2020 Dec 2. J Biol Chem. 2021. PMID: 33243834 Free PMC article.
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y. Tan M, et al. Among authors: hirschey md. Cell Metab. 2014 Apr 1;19(4):605-17. doi: 10.1016/j.cmet.2014.03.014. Cell Metab. 2014. PMID: 24703693 Free PMC article.
Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.
Glass OK, Inman BA, Broadwater G, Courneya KS, Mackey JR, Goruk S, Nelson ER, Jasper J, Field CJ, Bain JR, Muehlbauer M, Stevens RD, Hirschey MD, Jones LW. Glass OK, et al. Among authors: hirschey md. Br J Cancer. 2015 Mar 3;112(5):825-31. doi: 10.1038/bjc.2014.662. Epub 2015 Jan 13. Br J Cancer. 2015. PMID: 25584487 Free PMC article.
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.
Martin AS, Abraham DM, Hershberger KA, Bhatt DP, Mao L, Cui H, Liu J, Liu X, Muehlbauer MJ, Grimsrud PA, Locasale JW, Payne RM, Hirschey MD. Martin AS, et al. Among authors: hirschey md. JCI Insight. 2017 Jul 20;2(14):e93885. doi: 10.1172/jci.insight.93885. eCollection 2017 Jul 20. JCI Insight. 2017. PMID: 28724806 Free PMC article.
Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. Bharathi SS, et al. Among authors: hirschey md. J Biol Chem. 2013 Nov 22;288(47):33837-33847. doi: 10.1074/jbc.M113.510354. Epub 2013 Oct 11. J Biol Chem. 2013. PMID: 24121500 Free PMC article.
Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.
Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES. Otsubo C, et al. Among authors: hirschey md. J Biol Chem. 2015 Sep 25;290(39):23897-904. doi: 10.1074/jbc.M115.655837. Epub 2015 Aug 3. J Biol Chem. 2015. PMID: 26240137 Free PMC article.
Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.
Madsen AS, Andersen C, Daoud M, Anderson KA, Laursen JS, Chakladar S, Huynh FK, Colaço AR, Backos DS, Fristrup P, Hirschey MD, Olsen CA. Madsen AS, et al. Among authors: hirschey md. J Biol Chem. 2016 Mar 25;291(13):7128-41. doi: 10.1074/jbc.M115.668699. Epub 2016 Feb 9. J Biol Chem. 2016. PMID: 26861872 Free PMC article.
89 results