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Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses.
Banach BB, Cerutti G, Fahad AS, Shen CH, de Souza MO, Katsamba PS, Tsybovsky Y, Wang P, Nair MS, Huang Y, Urdániz IMF, Steiner PJ, Gutiérrez-González M, Liu L, López Acevedo SN, Nazzari A, Wolfe JR, Luo Y, Olia AS, Teng IT, Yu J, Zhou T, Reddem ER, Bimela J, Pan X, Madan B, Laflin AD, Nimrania R, Yuen KT, Whitehead TA, Ho DD, Kwong PD, Shapiro L, DeKosky BJ. Banach BB, et al. Among authors: shen ch. bioRxiv [Preprint]. 2021 Jan 3:2020.12.31.424987. doi: 10.1101/2020.12.31.424987. bioRxiv. 2021. PMID: 33442681 Free PMC article. Updated. Preprint.
Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation.
Cheung CS, Fruehwirth A, Paparoditis PCG, Shen CH, Foglierini M, Joyce MG, Leung K, Piccoli L, Rawi R, Silacci-Fregni C, Tsybovsky Y, Verardi R, Wang L, Wang S, Yang ES, Zhang B, Zhang Y, Chuang GY, Corti D, Mascola JR, Shapiro L, Kwong PD, Lanzavecchia A, Zhou T. Cheung CS, et al. Among authors: shen ch. Cell Rep. 2020 Sep 1;32(9):108088. doi: 10.1016/j.celrep.2020.108088. Cell Rep. 2020. PMID: 32877670 Free article.
Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains.
Rawi R, Rutten L, Lai YT, Olia AS, Blokland S, Juraszek J, Shen CH, Tsybovsky Y, Verardi R, Yang Y, Zhang B, Zhou T, Chuang GY, Kwong PD, Langedijk JPM. Rawi R, et al. Among authors: shen ch. Cell Rep. 2020 Nov 24;33(8):108432. doi: 10.1016/j.celrep.2020.108432. Cell Rep. 2020. PMID: 33238130 Free PMC article.
Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.
Chen X, Zhou T, Schmidt SD, Duan H, Cheng C, Chuang GY, Gu Y, Louder MK, Lin BC, Shen CH, Sheng Z, Zheng MX, Doria-Rose NA, Joyce MG, Shapiro L, Tian M, Alt FW, Kwong PD, Mascola JR. Chen X, et al. Among authors: shen ch. Immunity. 2021 Feb 9;54(2):324-339.e8. doi: 10.1016/j.immuni.2020.12.014. Epub 2021 Jan 15. Immunity. 2021. PMID: 33453152 Free PMC article.
Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.
Mukhamedova M, Wrapp D, Shen CH, Gilman MSA, Ruckwardt TJ, Schramm CA, Ault L, Chang L, Derrien-Colemyn A, Lucas SAM, Ransier A, Darko S, Phung E, Wang L, Zhang Y, Rush SA, Madan B, Stewart-Jones GBE, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Doria-Rose NA, Morabito KM, DeKosky BJ, Gaudinski MR, Chen GL, Crank MC, Misasi J, Sullivan NJ, Douek DC, Kwong PD, Graham BS, McLellan JS, Mascola JR. Mukhamedova M, et al. Among authors: shen ch. Immunity. 2021 Apr 13;54(4):769-780.e6. doi: 10.1016/j.immuni.2021.03.004. Epub 2021 Apr 5. Immunity. 2021. PMID: 33823129 Free PMC article. Clinical Trial.
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses.
Chuang GY, Shen CH, Cheung CS, Gorman J, Creanga A, Joyce MG, Leung K, Rawi R, Wang L, Yang ES, Yang Y, Zhang B, Zhang Y, Kanekiyo M, Zhou T, DeKosky BJ, Graham BS, Mascola JR, Kwong PD. Chuang GY, et al. Among authors: shen ch. Front Immunol. 2021 May 31;12:662909. doi: 10.3389/fimmu.2021.662909. eCollection 2021. Front Immunol. 2021. PMID: 34135892 Free PMC article.
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
Xu K, Wang Y, Shen CH, Chen Y, Zhang B, Liu K, Tsybovsky Y, Wang S, Farney SK, Gorman J, Stephens T, Verardi R, Yang Y, Zhou T, Chuang GY, Lanzavecchia A, Piccoli L, Kwong PD. Xu K, et al. Among authors: shen ch. Nat Commun. 2021 Jul 9;12(1):4226. doi: 10.1038/s41467-021-24291-6. Nat Commun. 2021. PMID: 34244481 Free PMC article.
Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses.
Stewart-Jones GBE, Gorman J, Ou L, Zhang B, Joyce MG, Yang L, Cheng C, Chuang GY, Foulds KE, Kong WP, Olia AS, Sastry M, Shen CH, Todd JP, Tsybovsky Y, Verardi R, Yang Y, Collins PL, Corti D, Lanzavecchia A, Scorpio DG, Mascola JR, Buchholz UJ, Kwong PD. Stewart-Jones GBE, et al. Among authors: shen ch. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2106196118. doi: 10.1073/pnas.2106196118. Proc Natl Acad Sci U S A. 2021. PMID: 34551978 Free PMC article.
Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses.
Banach BB, Cerutti G, Fahad AS, Shen CH, Oliveira De Souza M, Katsamba PS, Tsybovsky Y, Wang P, Nair MS, Huang Y, Francino-Urdániz IM, Steiner PJ, Gutiérrez-González M, Liu L, López Acevedo SN, Nazzari AF, Wolfe JR, Luo Y, Olia AS, Teng IT, Yu J, Zhou T, Reddem ER, Bimela J, Pan X, Madan B, Laflin AD, Nimrania R, Yuen KY, Whitehead TA, Ho DD, Kwong PD, Shapiro L, DeKosky BJ. Banach BB, et al. Among authors: shen ch. Cell Rep. 2021 Oct 5;37(1):109771. doi: 10.1016/j.celrep.2021.109771. Epub 2021 Sep 28. Cell Rep. 2021. PMID: 34587480 Free PMC article.
Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies.
Cottrell CA, Manne K, Kong R, Wang S, Zhou T, Chuang GY, Edwards RJ, Henderson R, Janowska K, Kopp M, Lin BC, Louder MK, Olia AS, Rawi R, Shen CH, Taft JD, Torres JL, Wu NR, Zhang B, Doria-Rose NA, Cohen MS, Haynes BF, Shapiro L, Ward AB, Acharya P, Mascola JR, Kwong PD. Cottrell CA, et al. Among authors: shen ch. Cell Rep. 2021 Nov 2;37(5):109922. doi: 10.1016/j.celrep.2021.109922. Cell Rep. 2021. PMID: 34731616 Free PMC article.
598 results