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735 results

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Page 1
NINJ1 mediates plasma membrane rupture during lytic cell death.
Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, Li Q, Sandoval W, Yan D, Kang J, Xu M, Zhang J, Lee WP, McKenzie BS, Ulas G, Payandeh J, Roose-Girma M, Modrusan Z, Reja R, Sagolla M, Webster JD, Cho V, Andrews TD, Morris LX, Miosge LA, Goodnow CC, Bertram EM, Dixit VM. Kayagaki N, et al. Nature. 2021 Mar;591(7848):131-136. doi: 10.1038/s41586-021-03218-7. Epub 2021 Jan 20. Nature. 2021. PMID: 33472215
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM. Kayagaki N, et al. Nature. 2015 Oct 29;526(7575):666-71. doi: 10.1038/nature15541. Epub 2015 Sep 16. Nature. 2015. PMID: 26375259
Cryopyrin activates the inflammasome in response to toxins and ATP.
Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Mariathasan S, et al. Nature. 2006 Mar 9;440(7081):228-32. doi: 10.1038/nature04515. Epub 2006 Jan 11. Nature. 2006. PMID: 16407890
IRF2 transcriptionally induces GSDMD expression for pyroptosis.
Kayagaki N, Lee BL, Stowe IB, Kornfeld OS, O'Rourke K, Mirrashidi KM, Haley B, Watanabe C, Roose-Girma M, Modrusan Z, Kummerfeld S, Reja R, Zhang Y, Cho V, Andrews TD, Morris LX, Goodnow CC, Bertram EM, Dixit VM. Kayagaki N, et al. Sci Signal. 2019 May 21;12(582):eaax4917. doi: 10.1126/scisignal.aax4917. Sci Signal. 2019. PMID: 31113851
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker JS, O'Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR, Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJ, Leong KG, Dueber EC, Maecker H, Huang DC, Dixit VM. Wertz IE, et al. Nature. 2011 Mar 3;471(7336):110-4. doi: 10.1038/nature09779. Nature. 2011. PMID: 21368834
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, Maecker H, O'Rourke K, Bazan F, Eastham-Anderson J, Yue P, Dornan D, Huang DC, Dixit VM. Schwickart M, et al. Nature. 2010 Jan 7;463(7277):103-7. doi: 10.1038/nature08646. Epub 2009 Dec 20. Nature. 2010. PMID: 20023629
735 results