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Heme Oxygenase-1 as a Pharmacological Target for Host-Directed Therapy to Limit Tuberculosis Associated Immunopathology.
Antioxidants (Basel). 2021 Jan 26;10(2):177. doi: 10.3390/antiox10020177.
Antioxidants (Basel). 2021.
PMID: 33530574
Free PMC article.
Review.
Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis.
Pacl HT, Reddy VP, Saini V, Chinta KC, Steyn AJC.
Pacl HT, et al.
Pathog Dis. 2018 Jul 1;76(5):fty036. doi: 10.1093/femspd/fty036.
Pathog Dis. 2018.
PMID: 29873719
Free PMC article.
Item in Clipboard
Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis.
Rahman MA, Cumming BM, Addicott KW, Pacl HT, Russell SL, Nargan K, Naidoo T, Ramdial PK, Adamson JH, Wang R, Steyn AJC.
Rahman MA, et al. Among authors: pacl ht.
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6663-6674. doi: 10.1073/pnas.1919211117. Epub 2020 Mar 5.
Proc Natl Acad Sci U S A. 2020.
PMID: 32139610
Free PMC article.
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Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy.
Cumming BM, Pacl HT, Steyn AJC.
Cumming BM, et al. Among authors: pacl ht.
Front Cell Infect Microbiol. 2020 Sep 18;10:576596. doi: 10.3389/fcimb.2020.576596. eCollection 2020.
Front Cell Infect Microbiol. 2020.
PMID: 33072629
Free PMC article.
Review.
Item in Clipboard
A high-resolution 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions.
Wells G, Glasgow JN, Nargan K, Lumamba K, Madansein R, Maharaj K, Perumal LY, Matthew M, Hunter RL, Pacl H, Peabody Lever JE, Stanford DD, Singh SP, Bajpai P, Manne U, Benson PV, Rowe SM, le Roux S, Sigal A, Tshibalanganda M, Wells C, du Plessis A, Msimang M, Naidoo T, Steyn AJC.
Wells G, et al.
EMBO Mol Med. 2022 Nov 8;14(11):e16283. doi: 10.15252/emmm.202216283. Epub 2022 Oct 26.
EMBO Mol Med. 2022.
PMID: 36285507
Free PMC article.
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NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis.
Pacl HT, Chinta KC, Reddy VP, Nadeem S, Sevalkar RR, Nargan K, Lumamba K, Naidoo T, Glasgow JN, Agarwal A, Steyn AJC.
Pacl HT, et al.
Nat Commun. 2023 Sep 6;14(1):5472. doi: 10.1038/s41467-023-40545-x.
Nat Commun. 2023.
PMID: 37673914
Free PMC article.
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Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase.
Pacl HT, Tipper JL, Sevalkar RR, Crouse A, Crowder C; UAB Precision Medicine Institute; Ahmad S, Ahmad A, Holder GD, Kuhlman CJ, Chinta KC, Nadeem S, Green TJ, Petit CM, Steyn AJC, Might M, Harrod KS.
Pacl HT, et al.
bioRxiv [Preprint]. 2021 Jul 27:2021.07.13.449251. doi: 10.1101/2021.07.13.449251.
bioRxiv. 2021.
PMID: 34282419
Free PMC article.
Preprint.
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