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CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.
Hansen JD, Correa M, Alexander M, Nagy M, Huang D, Sapienza J, Lu G, LeBrun LA, Cathers BE, Zhang W, Tang Y, Ammirante M, Narla RK, Piccotti JR, Pourdehnad M, Lopez-Girona A. Hansen JD, et al. Among authors: ammirante m. J Med Chem. 2021 Feb 25;64(4):1835-1843. doi: 10.1021/acs.jmedchem.0c01489. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33591756
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
Ammirante M, Rosati A, Arra C, Basile A, Falco A, Festa M, Pascale M, d'Avenia M, Marzullo L, Belisario MA, De Marco M, Barbieri A, Giudice A, Chiappetta G, Vuttariello E, Monaco M, Bonelli P, Salvatore G, Di Benedetto M, Deshmane SL, Khalili K, Turco MC, Leone A. Ammirante M, et al. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7497-502. doi: 10.1073/pnas.0907696107. Epub 2010 Apr 5. Proc Natl Acad Sci U S A. 2010. PMID: 20368414 Free PMC article.
The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand.
Chiappetta G, Ammirante M, Basile A, Rosati A, Festa M, Monaco M, Vuttariello E, Pasquinelli R, Arra C, Zerilli M, Todaro M, Stassi G, Pezzullo L, Gentilella A, Tosco A, Pascale M, Marzullo L, Belisario MA, Turco MC, Leone A. Chiappetta G, et al. Among authors: ammirante m. J Clin Endocrinol Metab. 2007 Mar;92(3):1159-63. doi: 10.1210/jc.2006-1712. Epub 2006 Dec 12. J Clin Endocrinol Metab. 2007. PMID: 17164298
Apoptosis inhibition in cancer cells: a novel molecular pathway that involves BAG3 protein.
Rosati A, Ammirante M, Gentilella A, Basile A, Festa M, Pascale M, Marzullo L, Belisario MA, Tosco A, Franceschelli S, Moltedo O, Pagliuca G, Lerose R, Turco MC. Rosati A, et al. Among authors: ammirante m. Int J Biochem Cell Biol. 2007;39(7-8):1337-42. doi: 10.1016/j.biocel.2007.03.007. Epub 2007 Mar 15. Int J Biochem Cell Biol. 2007. PMID: 17493862 Review.
1-Methoxy-canthin-6-one induces c-Jun NH2-terminal kinase-dependent apoptosis and synergizes with tumor necrosis factor-related apoptosis-inducing ligand activity in human neoplastic cells of hematopoietic or endodermal origin.
Ammirante M, Di Giacomo R, De Martino L, Rosati A, Festa M, Gentilella A, Pascale MC, Belisario MA, Leone A, Turco MC, De Feo V. Ammirante M, et al. Cancer Res. 2006 Apr 15;66(8):4385-93. doi: 10.1158/0008-5472.CAN-05-3895. Cancer Res. 2006. PMID: 16618764
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