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Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.
Khosravi-Maharlooei M, Li H, Hoelzl M, Zhao G, Ruiz A, Misra A, Li Y, Teteloshvili N, Nauman G, Danzl N, Ding X, Pinker EY, Obradovic A, Yang YG, Iuga A, Creusot RJ, Winchester R, Sykes M. Khosravi-Maharlooei M, et al. Among authors: winchester r. J Autoimmun. 2021 May;119:102612. doi: 10.1016/j.jaut.2021.102612. Epub 2021 Feb 19. J Autoimmun. 2021. PMID: 33611150 Free PMC article.
Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire.
Khosravi-Maharlooei M, Obradovic A, Misra A, Motwani K, Holzl M, Seay HR, DeWolf S, Nauman G, Danzl N, Li H, Ho SH, Winchester R, Shen Y, Brusko TM, Sykes M. Khosravi-Maharlooei M, et al. Among authors: winchester r. J Clin Invest. 2019 Mar 28;129(6):2446-2462. doi: 10.1172/JCI124358. J Clin Invest. 2019. PMID: 30920391 Free PMC article.
HSC extrinsic sex-related and intrinsic autoimmune disease-related human B-cell variation is recapitulated in humanized mice.
Borsotti C, Danzl NM, Nauman G, Hölzl MA, French C, Chavez E, Khosravi-Maharlooei M, Glauzy S, Delmotte FR, Meffre E, Savage DG, Campbell SR, Goland R, Greenberg E, Bi J, Satwani P, Yang S, Bathon J, Winchester R, Sykes M. Borsotti C, et al. Among authors: winchester r. Blood Adv. 2017 Oct 13;1(23):2007-2018. doi: 10.1182/bloodadvances.2017006932. eCollection 2017 Oct 24. Blood Adv. 2017. PMID: 29296847 Free PMC article.
Quantifying size and diversity of the human T cell alloresponse.
DeWolf S, Grinshpun B, Savage T, Lau SP, Obradovic A, Shonts B, Yang S, Morris H, Zuber J, Winchester R, Sykes M, Shen Y. DeWolf S, et al. Among authors: winchester r. JCI Insight. 2018 Aug 9;3(15):e121256. doi: 10.1172/jci.insight.121256. eCollection 2018 Aug 9. JCI Insight. 2018. PMID: 30089728 Free PMC article.
Hypercholesterolemia induces T cell expansion in humanized immune mice.
Proto JD, Doran AC, Subramanian M, Wang H, Zhang M, Sozen E, Rymond CC, Kuriakose G, D'Agati V, Winchester R, Sykes M, Yang YG, Tabas I. Proto JD, et al. Among authors: winchester r. J Clin Invest. 2018 Jun 1;128(6):2370-2375. doi: 10.1172/JCI97785. Epub 2018 Apr 30. J Clin Invest. 2018. PMID: 29708512 Free PMC article.
A model for personalized in vivo analysis of human immune responsiveness.
Kalscheuer H, Danzl N, Onoe T, Faust T, Winchester R, Goland R, Greenberg E, Spitzer TR, Savage DG, Tahara H, Choi G, Yang YG, Sykes M. Kalscheuer H, et al. Among authors: winchester r. Sci Transl Med. 2012 Mar 14;4(125):125ra30. doi: 10.1126/scitranslmed.3003481. Sci Transl Med. 2012. PMID: 22422991 Free PMC article.
Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney-Bone Marrow Transplantation to Induce Transplantation Tolerance.
Sprangers B, DeWolf S, Savage TM, Morokata T, Obradovic A, LoCascio SA, Shonts B, Zuber J, Lau SP, Shah R, Morris H, Steshenko V, Zorn E, Preffer FI, Olek S, Dombkowski DM, Turka LA, Colvin R, Winchester R, Kawai T, Sykes M. Sprangers B, et al. Among authors: winchester r. Am J Transplant. 2017 Aug;17(8):2020-2032. doi: 10.1111/ajt.14251. Epub 2017 Apr 10. Am J Transplant. 2017. PMID: 28251801 Free PMC article.
297 results