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Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization.
Turner HL, Andrabi R, Cottrell CA, Richey ST, Song G, Callaghan S, Anzanello F, Moyer TJ, Abraham W, Melo M, Silva M, Scaringi N, Rakasz EG, Sattentau Q, Irvine DJ, Burton DR, Ward AB. Turner HL, et al. Among authors: abraham w. bioRxiv [Preprint]. 2021 Feb 17:2021.02.16.431310. doi: 10.1101/2021.02.16.431310. bioRxiv. 2021. PMID: 33619491 Free PMC article. Updated. Preprint.
Engineered immunogen binding to alum adjuvant enhances humoral immunity.
Moyer TJ, Kato Y, Abraham W, Chang JYH, Kulp DW, Watson N, Turner HL, Menis S, Abbott RK, Bhiman JN, Melo MB, Simon HA, Herrera-De la Mata S, Liang S, Seumois G, Agarwal Y, Li N, Burton DR, Ward AB, Schief WR, Crotty S, Irvine DJ. Moyer TJ, et al. Among authors: abraham w. Nat Med. 2020 Mar;26(3):430-440. doi: 10.1038/s41591-020-0753-3. Epub 2020 Feb 17. Nat Med. 2020. PMID: 32066977 Free PMC article.
Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity.
Moyer TJ, Kato Y, Abraham W, Chang JYH, Kulp DW, Watson N, Turner HL, Menis S, Abbott RK, Bhiman JN, Melo MB, Simon HA, Herrera-De la Mata S, Liang S, Seumois G, Agarwal Y, Li N, Burton DR, Ward AB, Schief WR, Crotty S, Irvine DJ. Moyer TJ, et al. Among authors: abraham w. Nat Med. 2020 May;26(5):804. doi: 10.1038/s41591-020-0861-0. Nat Med. 2020. PMID: 32405059 Free PMC article.
Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization.
Turner HL, Andrabi R, Cottrell CA, Richey ST, Song G, Callaghan S, Anzanello F, Moyer TJ, Abraham W, Melo M, Silva M, Scaringi N, Rakasz EG, Sattentau QJ, Irvine DJ, Burton DR, Ward AB. Turner HL, et al. Among authors: abraham w. Sci Adv. 2021 Jul 28;7(31):eabh2791. doi: 10.1126/sciadv.abh2791. Print 2021 Jul. Sci Adv. 2021. PMID: 34321200 Free PMC article.
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity.
Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, Irvine DJ. Silva M, et al. Among authors: abraham w. Sci Immunol. 2021 Dec 3;6(66):eabf1152. doi: 10.1126/sciimmunol.abf1152. Epub 2021 Dec 3. Sci Immunol. 2021. PMID: 34860581 Free PMC article.
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2.
Rodrigues KA, Rodriguez-Aponte SA, Dalvie NC, Lee JH, Abraham W, Carnathan DG, Jimenez LE, Ngo JT, Chang JYH, Zhang Z, Yu J, Chang A, Nakao C, Goodwin B, Naranjo CA, Zhang L, Silva M, Barouch DH, Silvestri G, Crotty S, Love JC, Irvine DJ. Rodrigues KA, et al. Among authors: abraham w. Sci Adv. 2021 Dec 10;7(50):eabj6538. doi: 10.1126/sciadv.abj6538. Epub 2021 Dec 8. Sci Adv. 2021. PMID: 34878851 Free PMC article.
Low protease activity in B cell follicles promotes retention of intact antigens after immunization.
Aung A, Cui A, Maiorino L, Amini AP, Gregory JR, Bukenya M, Zhang Y, Lee H, Cottrell CA, Morgan DM, Silva M, Suh H, Kirkpatrick JD, Amlashi P, Remba T, Froehle LM, Xiao S, Abraham W, Adams J, Love JC, Huyett P, Kwon DS, Hacohen N, Schief WR, Bhatia SN, Irvine DJ. Aung A, et al. Among authors: abraham w. Science. 2023 Jan 27;379(6630):eabn8934. doi: 10.1126/science.abn8934. Epub 2023 Jan 27. Science. 2023. PMID: 36701450 Free PMC article.
Optimization of an alum-anchored clinical HIV vaccine candidate.
Rodrigues KA, Cottrell CA, Steichen JM, Groschel B, Abraham W, Suh H, Agarwal Y, Ni K, Chang JYH, Yousefpour P, Melo MB, Schief WR, Irvine DJ. Rodrigues KA, et al. Among authors: abraham w. NPJ Vaccines. 2023 Aug 12;8(1):117. doi: 10.1038/s41541-023-00711-0. NPJ Vaccines. 2023. PMID: 37573422 Free PMC article.
Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons.
Truex NL, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, Sementa D, Touti F, Keskin DB, Wu CJ, Irvine DJ, Gómez-Bombarelli R, Pentelute BL. Truex NL, et al. Among authors: abraham w. bioRxiv [Preprint]. 2023 Sep 26:2023.08.22.554289. doi: 10.1101/2023.08.22.554289. bioRxiv. 2023. PMID: 37662211 Free PMC article. Updated. Preprint.
1,244 results