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Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates.
Hangartner L, Beauparlant D, Rakasz E, Nedellec R, Hozé N, McKenney K, Martins MA, Seabright GE, Allen JD, Weiler AM, Friedrich TC, Regoes RR, Crispin M, Burton DR. Hangartner L, et al. Among authors: seabright ge. Sci Transl Med. 2021 Mar 17;13(585):eabe3349. doi: 10.1126/scitranslmed.abe3349. Sci Transl Med. 2021. PMID: 33731434 Free PMC article.
Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers.
Pritchard LK, Vasiljevic S, Ozorowski G, Seabright GE, Cupo A, Ringe R, Kim HJ, Sanders RW, Doores KJ, Burton DR, Wilson IA, Ward AB, Moore JP, Crispin M. Pritchard LK, et al. Among authors: seabright ge. Cell Rep. 2015 Jun 16;11(10):1604-13. doi: 10.1016/j.celrep.2015.05.017. Epub 2015 Jun 4. Cell Rep. 2015. PMID: 26051934 Free PMC article.
Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.
Pritchard LK, Spencer DI, Royle L, Bonomelli C, Seabright GE, Behrens AJ, Kulp DW, Menis S, Krumm SA, Dunlop DC, Crispin DJ, Bowden TA, Scanlan CN, Ward AB, Schief WR, Doores KJ, Crispin M. Pritchard LK, et al. Among authors: seabright ge. Nat Commun. 2015 Jun 24;6:7479. doi: 10.1038/ncomms8479. Nat Commun. 2015. PMID: 26105115 Free PMC article.
Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein.
Behrens AJ, Vasiljevic S, Pritchard LK, Harvey DJ, Andev RS, Krumm SA, Struwe WB, Cupo A, Kumar A, Zitzmann N, Seabright GE, Kramer HB, Spencer DI, Royle L, Lee JH, Klasse PJ, Burton DR, Wilson IA, Ward AB, Sanders RW, Moore JP, Doores KJ, Crispin M. Behrens AJ, et al. Among authors: seabright ge. Cell Rep. 2016 Mar 22;14(11):2695-706. doi: 10.1016/j.celrep.2016.02.058. Epub 2016 Mar 10. Cell Rep. 2016. PMID: 26972002 Free PMC article.
Structure of the Lassa virus glycan shield provides a model for immunological resistance.
Watanabe Y, Raghwani J, Allen JD, Seabright GE, Li S, Moser F, Huiskonen JT, Strecker T, Bowden TA, Crispin M. Watanabe Y, et al. Among authors: seabright ge. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7320-7325. doi: 10.1073/pnas.1803990115. Epub 2018 Jun 25. Proc Natl Acad Sci U S A. 2018. PMID: 29941589 Free PMC article.
Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.
Struwe WB, Chertova E, Allen JD, Seabright GE, Watanabe Y, Harvey DJ, Medina-Ramirez M, Roser JD, Smith R, Westcott D, Keele BF, Bess JW Jr, Sanders RW, Lifson JD, Moore JP, Crispin M. Struwe WB, et al. Among authors: seabright ge. Cell Rep. 2018 Aug 21;24(8):1958-1966.e5. doi: 10.1016/j.celrep.2018.07.080. Cell Rep. 2018. PMID: 30134158 Free PMC article.
Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes.
Ringe RP, Pugach P, Cottrell CA, LaBranche CC, Seabright GE, Ketas TJ, Ozorowski G, Kumar S, Schorcht A, van Gils MJ, Crispin M, Montefiori DC, Wilson IA, Ward AB, Sanders RW, Klasse PJ, Moore JP. Ringe RP, et al. Among authors: seabright ge. J Virol. 2019 Feb 5;93(4):e01656-18. doi: 10.1128/JVI.01656-18. Print 2019 Feb 15. J Virol. 2019. PMID: 30487280 Free PMC article.
19 results