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Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study.
Young BE, Wei WE, Fong SW, Mak TM, Anderson DE, Chan YH, Pung R, Heng CS, Ang LW, Zheng AKE, Lee B, Kalimuddin S, Pada S, Tambyah PA, Parthasarathy P, Tan SY, Sun L, Smith GJ, Lin RTP, Leo YS, Renia L, Wang LF, Ng LF, Maurer-Stroh S, Lye DC, Lee VJ. Young BE, et al. Among authors: lee vj, lee b. EBioMedicine. 2021 Apr;66:103319. doi: 10.1016/j.ebiom.2021.103319. Epub 2021 Apr 8. EBioMedicine. 2021. PMID: 33840632 Free PMC article.
Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity.
Amrun SN, Lee CY, Lee B, Fong SW, Young BE, Chee RS, Yeo NK, Torres-Ruesta A, Carissimo G, Poh CM, Chang ZW, Tay MZ, Chan YH, Chen MI, Low JG, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Leo YS, Lye DC, Renia L, Ng LFP. Amrun SN, et al. Among authors: lee cy, lee b. EBioMedicine. 2020 Aug;58:102911. doi: 10.1016/j.ebiom.2020.102911. Epub 2020 Jul 22. EBioMedicine. 2020. PMID: 32711254 Free PMC article.
Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study.
Young BE, Fong SW, Chan YH, Mak TM, Ang LW, Anderson DE, Lee CY, Amrun SN, Lee B, Goh YS, Su YCF, Wei WE, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Chen YYC, Barkham T, Lin RTP, Maurer-Stroh S, Leo YS, Wang LF, Renia L, Lee VJ, Smith GJD, Lye DC, Ng LFP. Young BE, et al. Among authors: lee vj, lee cy, lee b. Lancet. 2020 Aug 29;396(10251):603-611. doi: 10.1016/S0140-6736(20)31757-8. Epub 2020 Aug 18. Lancet. 2020. PMID: 32822564 Free PMC article.
Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity.
Young BE, Ong SWX, Ng LFP, Anderson DE, Chia WN, Chia PY, Ang LW, Mak TM, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Fong SW, Chan YH, Tan CW, Lee B, Rötzschke O, Ding Y, Tambyah P, Low JGH, Cui L, Barkham T, Lin RTP, Leo YS, Renia L, Wang LF, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. Young BE, et al. Among authors: lee b. Clin Infect Dis. 2021 Nov 2;73(9):e2932-e2942. doi: 10.1093/cid/ciaa1280. Clin Infect Dis. 2021. PMID: 32856707 Free PMC article.
Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection.
Fong SW, Yeo NK, Chan YH, Goh YS, Amrun SN, Ang N, Rajapakse MP, Lum J, Foo S, Lee CY, Carissimo G, Chee RS, Torres-Ruesta A, Tay MZ, Chang ZW, Poh CM, Young BE, Tambyah PA, Kalimuddin S, Leo YS, Lye DC, Lee B, Biswas S, Howland SW, Renia L, Ng LFP. Fong SW, et al. Among authors: lee cy, lee b. J Clin Immunol. 2022 Feb;42(2):214-229. doi: 10.1007/s10875-021-01142-z. Epub 2021 Oct 30. J Clin Immunol. 2022. PMID: 34716845 Free PMC article.
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals.
Lim J, Puan KJ, Wang LW, Teng KWW, Loh CY, Tan KP, Carissimo G, Chan YH, Poh CM, Lee CY, Fong SW, Yeo NK, Chee RS, Amrun SN, Chang ZW, Tay MZ, Torres-Ruesta A, Leo Fernandez N, How W, Andiappan AK, Lee W, Duan K, Tan SY, Yan G, Kalimuddin S, Lye DC, Leo YS, Ong SWX, Young BE, Renia L, Ng LFP, Lee B, Rötzschke O. Lim J, et al. Among authors: lee w, lee cy, lee b. Front Immunol. 2021 Nov 19;12:710217. doi: 10.3389/fimmu.2021.710217. eCollection 2021. Front Immunol. 2021. PMID: 34867943 Free PMC article.
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19.
Carissimo G, Xu W, Kwok I, Abdad MY, Chan YH, Fong SW, Puan KJ, Lee CY, Yeo NK, Amrun SN, Chee RS, How W, Chan S, Fan BE, Andiappan AK, Lee B, Rötzschke O, Young BE, Leo YS, Lye DC, Renia L, Ng LG, Larbi A, Ng LF. Carissimo G, et al. Among authors: lee cy, lee b. Nat Commun. 2020 Oct 16;11(1):5243. doi: 10.1038/s41467-020-19080-6. Nat Commun. 2020. PMID: 33067472 Free PMC article.
Sensitive detection of total anti-Spike antibodies and isotype switching in asymptomatic and symptomatic individuals with COVID-19.
Goh YS, Chavatte JM, Lim Jieling A, Lee B, Hor PX, Amrun SN, Lee CY, Chee RS, Wang B, Lee CY, Ngoh EZX, Wang CI, Young BE, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Chen MI, Leo YS, Lye DC, Ng LFP, Lin RTP, Renia L. Goh YS, et al. Among authors: lee cy, lee b. Cell Rep Med. 2021 Feb 16;2(2):100193. doi: 10.1016/j.xcrm.2021.100193. Epub 2021 Jan 16. Cell Rep Med. 2021. PMID: 33495757 Free PMC article.
Human neutralising antibodies elicited by SARS-CoV-2 non-D614G variants offer cross-protection against the SARS-CoV-2 D614G variant.
Lee CY, Amrun SN, Chee RS, Goh YS, Mak TM, Octavia S, Yeo NK, Chang ZW, Tay MZ, Torres-Ruesta A, Carissimo G, Poh CM, Fong SW, Bei W, Lee S, Young BE, Tan SY, Leo YS, Lye DC, Lin RT, Maurer-Stroh S, Lee B, Wang CI, Renia L, Ng LF. Lee CY, et al. Among authors: lee s, lee b. Clin Transl Immunology. 2021 Feb 22;10(2):e1241. doi: 10.1002/cti2.1241. eCollection 2021. Clin Transl Immunology. 2021. PMID: 33628442 Free PMC article.
Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2.
Chan YH, Fong SW, Poh CM, Carissimo G, Yeo NK, Amrun SN, Goh YS, Lim J, Xu W, Chee RS, Torres-Ruesta A, Lee CY, Tay MZ, Chang ZW, Lee WH, Wang B, Tan SY, Kalimuddin S, Young BE, Leo YS, Wang CI, Lee B, Rötzschke O, Lye DC, Renia L, Ng LFP. Chan YH, et al. Among authors: lee cy, lee wh, lee b. EMBO Mol Med. 2021 Jun 7;13(6):e14045. doi: 10.15252/emmm.202114045. Epub 2021 May 27. EMBO Mol Med. 2021. PMID: 33961735 Free PMC article.
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