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Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring.
Mascharak S, desJardins-Park HE, Davitt MF, Griffin M, Borrelli MR, Moore AL, Chen K, Duoto B, Chinta M, Foster DS, Shen AH, Januszyk M, Kwon SH, Wernig G, Wan DC, Lorenz HP, Gurtner GC, Longaker MT. Mascharak S, et al. Among authors: duoto b. Science. 2021 Apr 23;372(6540):eaba2374. doi: 10.1126/science.aba2374. Science. 2021. PMID: 33888614 Free PMC article.
Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis.
Leavitt T, Hu MS, Borrelli MR, Januszyk M, Garcia JT, Ransom RC, Mascharak S, desJardins-Park HE, Litzenburger UM, Walmsley GG, Marshall CD, Moore AL, Duoto B, Adem S, Foster DS, Salhotra A, Shen AH, Griffin M, Shen EZ, Barnes LA, Zielins ER, Maan ZN, Wei Y, Chan CKF, Wan DC, Lorenz HP, Chang HY, Gurtner GC, Longaker MT. Leavitt T, et al. Among authors: duoto b. Cell Rep. 2020 Nov 10;33(6):108356. doi: 10.1016/j.celrep.2020.108356. Cell Rep. 2020. PMID: 33176144 Free PMC article.
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models.
Griffin MF, Borrelli MR, Garcia JT, Januszyk M, King M, Lerbs T, Cui L, Moore AL, Shen AH, Mascharak S, Diaz Deleon NM, Adem S, Taylor WL, desJardins-Park HE, Gastou M, Patel RA, Duoto BA, Sokol J, Wei Y, Foster D, Chen K, Wan DC, Gurtner GC, Lorenz HP, Chang HY, Wernig G, Longaker MT. Griffin MF, et al. Among authors: duoto ba. Sci Transl Med. 2021 Sep;13(609):eabb3312. doi: 10.1126/scitranslmed.abb3312. Epub 2021 Sep 1. Sci Transl Med. 2021. PMID: 34516825 Free PMC article.
Doxycycline Reduces Scar Thickness and Improves Collagen Architecture.
Moore AL, desJardins-Park HE, Duoto BA, Mascharak S, Murphy MP, Irizarry DM, Foster DS, Jones RE, Barnes LA, Marshall CD, Ransom RC, Wernig G, Longaker MT. Moore AL, et al. Among authors: duoto ba. Ann Surg. 2020 Jul;272(1):183-193. doi: 10.1097/SLA.0000000000003172. Ann Surg. 2020. PMID: 30585822 Free PMC article.