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Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations.
Dulla K, Slijkerman R, van Diepen HC, Albert S, Dona M, Beumer W, Turunen JJ, Chan HL, Schulkens IA, Vorthoren L, den Besten C, Buil L, Schmidt I, Miao J, Venselaar H, Zang J, Neuhauss SCF, Peters T, Broekman S, Pennings R, Kremer H, Platenburg G, Adamson P, de Vrieze E, van Wijk E. Dulla K, et al. Among authors: den besten c. Mol Ther. 2021 Aug 4;29(8):2441-2455. doi: 10.1016/j.ymthe.2021.04.024. Epub 2021 Apr 23. Mol Ther. 2021. PMID: 33895329 Free PMC article.
Therapy with 2'-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption.
Janssen MJ, Nieskens TTG, Steevels TAM, Caetano-Pinto P, den Braanker D, Mulder M, Ponstein Y, Jones S, Masereeuw R, den Besten C, Wilmer MJ. Janssen MJ, et al. Among authors: den besten c. Mol Ther Nucleic Acids. 2019 Dec 6;18:298-307. doi: 10.1016/j.omtn.2019.08.025. Epub 2019 Sep 6. Mol Ther Nucleic Acids. 2019. PMID: 31610379 Free PMC article.
Impurities in Oligonucleotide Drug Substances and Drug Products.
Capaldi D, Teasdale A, Henry S, Akhtar N, den Besten C, Gao-Sheridan S, Kretschmer M, Sharpe N, Andrews B, Burm B, Foy J. Capaldi D, et al. Among authors: den besten c. Nucleic Acid Ther. 2017 Dec;27(6):309-322. doi: 10.1089/nat.2017.0691. Epub 2017 Nov 10. Nucleic Acid Ther. 2017. PMID: 29125795
The liver, kidney, and thyroid toxicity of chlorinated benzenes.
den Besten C, Vet JJ, Besselink HT, Kiel GS, van Berkel BJ, Beems R, van Bladeren PJ. den Besten C, et al. Toxicol Appl Pharmacol. 1991 Oct;111(1):69-81. doi: 10.1016/0041-008x(91)90135-2. Toxicol Appl Pharmacol. 1991. PMID: 1949037
35 results