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Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.
Smati S, Polizzi A, Fougerat A, Ellero-Simatos S, Blum Y, Lippi Y, Régnier M, Laroyenne A, Huillet M, Arif M, Zhang C, Lasserre F, Marrot A, Al Saati T, Wan J, Sommer C, Naylies C, Batut A, Lukowicz C, Fougeray T, Tramunt B, Dubot P, Smith L, Bertrand-Michel J, Hennuyer N, Pradere JP, Staels B, Burcelin R, Lenfant F, Arnal JF, Levade T, Gamet-Payrastre L, Lagarrigue S, Loiseau N, Lotersztajn S, Postic C, Wahli W, Bureau C, Guillaume M, Mardinoglu A, Montagner A, Gourdy P, Guillou H. Smati S, et al. Among authors: wan j. Gut. 2022 Apr;71(4):807-821. doi: 10.1136/gutjnl-2020-323323. Epub 2021 Apr 26. Gut. 2022. PMID: 33903148 Free article.
Macrophage autophagy protects against liver fibrosis in mice.
Lodder J, Denaës T, Chobert MN, Wan J, El-Benna J, Pawlotsky JM, Lotersztajn S, Teixeira-Clerc F. Lodder J, et al. Among authors: wan j. Autophagy. 2015;11(8):1280-92. doi: 10.1080/15548627.2015.1058473. Autophagy. 2015. PMID: 26061908 Free PMC article.
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver.
Hegde P, Weiss E, Paradis V, Wan J, Mabire M, Sukriti S, Rautou PE, Albuquerque M, Picq O, Gupta AC, Ferrere G, Gilgenkrantz H, Kiaf B, Toubal A, Beaudoin L, Lettéron P, Moreau R, Lehuen A, Lotersztajn S. Hegde P, et al. Among authors: wan j. Nat Commun. 2018 Jun 1;9(1):2146. doi: 10.1038/s41467-018-04450-y. Nat Commun. 2018. PMID: 29858567 Free PMC article.
Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver.
Habib A, Chokr D, Wan J, Hegde P, Mabire M, Siebert M, Ribeiro-Parenti L, Le Gall M, Lettéron P, Pilard N, Mansouri A, Brouillet A, Tardelli M, Weiss E, Le Faouder P, Guillou H, Cravatt BF, Moreau R, Trauner M, Lotersztajn S. Habib A, et al. Among authors: wan j. Gut. 2019 Mar;68(3):522-532. doi: 10.1136/gutjnl-2018-316137. Epub 2018 Oct 9. Gut. 2019. PMID: 30301768
LC3-associated phagocytosis in myeloid cells, a fireman that restrains inflammation and liver fibrosis, via immunoreceptor inhibitory signaling.
Wan J, Weiss E, Ben Mkaddem S, Mabire M, Choinier PM, Thibault-Sogorb T, Hegde P, Bens M, Broer L, Gilgenkrantz H, Moreau R, Saveanu L, Codogno P, Monteiro RC, Lotersztajn S. Wan J, et al. Autophagy. 2020 Aug;16(8):1526-1528. doi: 10.1080/15548627.2020.1770979. Epub 2020 May 31. Autophagy. 2020. PMID: 32434445 Free PMC article.
MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming.
Mabire M, Hegde P, Hammoutene A, Wan J, Caër C, Sayegh RA, Cadoux M, Allaire M, Weiss E, Thibault-Sogorb T, Lantz O, Goodhardt M, Paradis V, de la Grange P, Gilgenkrantz H, Lotersztajn S. Mabire M, et al. Among authors: wan j. Nat Commun. 2023 Apr 1;14(1):1830. doi: 10.1038/s41467-023-37453-5. Nat Commun. 2023. PMID: 37005415 Free PMC article.
Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration.
Allaire M, Al Sayegh R, Mabire M, Hammoutene A, Siebert M, Caër C, Cadoux M, Wan J, Habib A, Le Gall M, de la Grange P, Guillou H, Postic C, Paradis V, Lotersztajn S, Gilgenkrantz H. Allaire M, et al. Among authors: wan j. JHEP Rep. 2023 May 16;5(8):100794. doi: 10.1016/j.jhepr.2023.100794. eCollection 2023 Aug. JHEP Rep. 2023. PMID: 37520673 Free PMC article.
6,121 results