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Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients.
Yan Q, He P, Huang X, Luo K, Zhang Y, Yi H, Wang Q, Li F, Hou R, Fan X, Li P, Liu X, Liang H, Deng Y, Chen Z, Chen Y, Mo X, Feng L, Xiong X, Li S, Han J, Qu L, Niu X, Chen L. Yan Q, et al. Among authors: xiong x. Emerg Microbes Infect. 2021 Dec;10(1):1097-1111. doi: 10.1080/22221751.2021.1925594. Emerg Microbes Infect. 2021. PMID: 33944697 Free PMC article.
A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape.
Feng B, Chen Z, Sun J, Xu T, Wang Q, Yi H, Niu X, Zhu J, Fan M, Hou R, Shao Y, Huang S, Li C, Hu P, Zheng P, He P, Luo J, Yan Q, Xiong X, Liu J, Zhao J, Chen L. Feng B, et al. Among authors: xiong x. Small Methods. 2022 Jul;6(7):e2200387. doi: 10.1002/smtd.202200387. Epub 2022 May 18. Small Methods. 2022. PMID: 35583124 Free PMC article.
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X. He P, et al. Among authors: xiong x. Nat Microbiol. 2022 Oct;7(10):1635-1649. doi: 10.1038/s41564-022-01235-4. Epub 2022 Sep 23. Nat Microbiol. 2022. PMID: 36151403 Free PMC article.
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants.
Yu H, Liu B, Zhang Y, Gao X, Wang Q, Xiang H, Peng X, Xie C, Wang Y, Hu P, Shi J, Shi Q, Zheng P, Feng C, Tang G, Liu X, Guo L, Lin X, Li J, Liu C, Huang Y, Yang N, Chen Q, Li Z, Su M, Yan Q, Pei R, Chen X, Liu L, Hu F, Liang D, Ke B, Ke C, Li F, He J, Wang M, Chen L, Xiong X, Tang X. Yu H, et al. Among authors: xiong x. Nat Commun. 2023 Feb 24;14(1):1058. doi: 10.1038/s41467-023-36761-0. Nat Commun. 2023. PMID: 36828833 Free PMC article.
Structural basis for broad coronavirus neutralization.
Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D. Sauer MM, et al. Among authors: xiong x. Nat Struct Mol Biol. 2021 Jun;28(6):478-486. doi: 10.1038/s41594-021-00596-4. Epub 2021 May 12. Nat Struct Mol Biol. 2021. PMID: 33981021
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike.
Qu K, Chen Q, Ciazynska KA, Liu B, Zhang X, Wang J, He Y, Guan J, He J, Liu T, Zhang X, Carter AP, Xiong X, Briggs JAG. Qu K, et al. Among authors: xiong x. PLoS Pathog. 2022 Jul 29;18(7):e1010583. doi: 10.1371/journal.ppat.1010583. eCollection 2022 Jul. PLoS Pathog. 2022. PMID: 35905112 Free PMC article.
Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody.
Xiong X, Corti D, Liu J, Pinna D, Foglierini M, Calder LJ, Martin SR, Lin YP, Walker PA, Collins PJ, Monne I, Suguitan AL Jr, Santos C, Temperton NJ, Subbarao K, Lanzavecchia A, Gamblin SJ, Skehel JJ. Xiong X, et al. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9430-5. doi: 10.1073/pnas.1510816112. Epub 2015 Jul 13. Proc Natl Acad Sci U S A. 2015. PMID: 26170284 Free PMC article.
SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses.
Carnell GW, Ciazynska KA, Wells DA, Xiong X, Aguinam ET, McLaughlin SH, Mallery D, Ebrahimi S, Ceron-Gutierrez L, Asbach B, Einhauser S, Wagner R, James LC, Doffinger R, Heeney JL, Briggs JAG. Carnell GW, et al. Among authors: xiong x. J Virol. 2021 Jul 12;95(15):e0020321. doi: 10.1128/JVI.00203-21. Epub 2021 Jul 12. J Virol. 2021. PMID: 33963055 Free PMC article.
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.
Mlcochova P, Collier D, Ritchie A, Assennato SM, Hosmillo M, Goel N, Meng B, Chatterjee K, Mendoza V, Temperton N, Kiss L, James LC, Ciazynska KA, Xiong X, Briggs JAG, Nathan JA, Mescia F, Bergamaschi L, Zhang H, Barmpounakis P, Demeris N, Skells R, Lyons PA, Bradley J, Baker S, Allain JP, Smith KGC, Bousfield R, Wilson M, Sparkes D, Amoroso G, Gkrania-Klotsas E, Hardwick S, Boyle A, Goodfellow I, Gupta RK; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration. Mlcochova P, et al. Among authors: xiong x. Cell Rep Med. 2020 Sep 22;1(6):100099. doi: 10.1016/j.xcrm.2020.100099. Epub 2020 Sep 1. Cell Rep Med. 2020. PMID: 32905045 Free PMC article.
5,282 results