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Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.
Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, Trembath RC, Wilkins MR; Regeneron Genetics Center; PAH Biobank Enrolling Centers’ Investigators; NIHR BioResource for Translational Research - Rare Diseases; National Cohort Study of Idiopathic and Heritable PAH; Morrell NW, Shen Y, Gräf S, Nichols WC, Chung WK. Zhu N, et al. Among authors: lawrie a. Genome Med. 2021 May 10;13(1):80. doi: 10.1186/s13073-021-00891-1. Genome Med. 2021. PMID: 33971972 Free PMC article.
Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.
Condliffe R, Pickworth JA, Hopkinson K, Walker SJ, Hameed AG, Suntharaligam J, Soon E, Treacy C, Pepke-Zaba J, Francis SE, Crossman DC, Newman CM, Elliot CA, Morton AC, Morrell NW, Kiely DG, Lawrie A. Condliffe R, et al. Among authors: lawrie a. Pulm Circ. 2012 Jan-Mar;2(1):21-7. doi: 10.4103/2045-8932.94819. Pulm Circ. 2012. PMID: 22558516 Free PMC article.
Pulmonary hypertension in COPD: results from the ASPIRE registry.
Hurdman J, Condliffe R, Elliot CA, Swift A, Rajaram S, Davies C, Hill C, Hamilton N, Armstrong IJ, Billings C, Pollard L, Wild JM, Lawrie A, Lawson R, Sabroe I, Kiely DG. Hurdman J, et al. Among authors: lawrie a. Eur Respir J. 2013 Jun;41(6):1292-301. doi: 10.1183/09031936.00079512. Epub 2012 Sep 27. Eur Respir J. 2013. PMID: 23018917 Free article.
Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.
Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW, Crossman DC, Newman CM, Kiely DG, Francis SE, Lawrie A. Hameed AG, et al. Among authors: lawrie a. J Exp Med. 2012 Oct 22;209(11):1919-35. doi: 10.1084/jem.20112716. Epub 2012 Oct 15. J Exp Med. 2012. PMID: 23071256 Free PMC article.
Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.
Rhodes CJ, Wharton J, Boon RA, Roexe T, Tsang H, Wojciak-Stothard B, Chakrabarti A, Howard LS, Gibbs JS, Lawrie A, Condliffe R, Elliot CA, Kiely DG, Huson L, Ghofrani HA, Tiede H, Schermuly R, Zeiher AM, Dimmeler S, Wilkins MR. Rhodes CJ, et al. Among authors: lawrie a. Am J Respir Crit Care Med. 2013 Feb 1;187(3):294-302. doi: 10.1164/rccm.201205-0839OC. Epub 2012 Dec 6. Am J Respir Crit Care Med. 2013. PMID: 23220912
Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension.
Spiekerkoetter E, Sung YK, Sudheendra D, Bill M, Aldred MA, van de Veerdonk MC, Vonk Noordegraaf A, Long-Boyle J, Dash R, Yang PC, Lawrie A, Swift AJ, Rabinovitch M, Zamanian RT. Spiekerkoetter E, et al. Among authors: lawrie a. Am J Respir Crit Care Med. 2015 Jul 15;192(2):254-7. doi: 10.1164/rccm.201411-2061LE. Am J Respir Crit Care Med. 2015. PMID: 26177174 Free PMC article. Clinical Trial. No abstract available.
Pulmonary artery denervation reduces pulmonary artery pressure and induces histological changes in an acute porcine model of pulmonary hypertension.
Rothman AM, Arnold ND, Chang W, Watson O, Swift AJ, Condliffe R, Elliot CA, Kiely DG, Suvarna SK, Gunn J, Lawrie A. Rothman AM, et al. Among authors: lawrie a. Circ Cardiovasc Interv. 2015 Nov;8(11):e002569. doi: 10.1161/CIRCINTERVENTIONS.115.002569. Circ Cardiovasc Interv. 2015. PMID: 26553697 Free PMC article.
363 results