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An oral antisense oligonucleotide for PCSK9 inhibition.
Gennemark P, Walter K, Clemmensen N, Rekić D, Nilsson CAM, Knöchel J, Hölttä M, Wernevik L, Rosengren B, Kakol-Palm D, Wang Y, Yu RZ, Geary RS, Riney SJ, Monia BP, Isaksson R, Jansson-Löfmark R, Rocha CSJ, Lindén D, Hurt-Camejo E, Crooke R, Tillman L, Rydén-Bergsten T, Carlsson B, Andersson U, Elebring M, Tivesten A, Davies N. Gennemark P, et al. Among authors: andersson u. Sci Transl Med. 2021 May 12;13(593):eabe9117. doi: 10.1126/scitranslmed.abe9117. Sci Transl Med. 2021. PMID: 33980578
Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats.
Hellmold H, Zhang H, Andersson U, Blomgren B, Holland T, Berg AL, Elebring M, Sjögren N, Bamberg K, Dahl B, Westerberg R, Dillner B, Tugwood J, Tugwood J, Roberts R, Lundholm E, Camejo G, Skånberg I, Evans J. Hellmold H, et al. Among authors: andersson u. Toxicol Sci. 2007 Jul;98(1):63-74. doi: 10.1093/toxsci/kfm094. Epub 2007 Apr 27. Toxicol Sci. 2007. PMID: 17468185
An Angle on MK2 Inhibition-Optimization and Evaluation of Prevention of Activation Inhibitors.
Hedström U, Norberg M, Evertsson E, Lever SR, Munck Af Rosenschöld M, Lönn H, Bold P, Käck H, Berntsson P, Vinblad J, Liu J, Welinder A, Karlsson J, Snijder A, Pardali K, Andersson U, Davis AM, Mogemark M. Hedström U, et al. Among authors: andersson u. ChemMedChem. 2019 Oct 4;14(19):1701-1709. doi: 10.1002/cmdc.201900303. Epub 2019 Aug 13. ChemMedChem. 2019. PMID: 31325352
Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism.
Danielsson C, Brask J, Sköld AC, Genead R, Andersson A, Andersson U, Stockling K, Pehrson R, Grinnemo KH, Salari S, Hellmold H, Danielsson B, Sylvén C, Elinder F. Danielsson C, et al. Among authors: andersson a, andersson u. Cardiovasc Res. 2013 Jan 1;97(1):23-32. doi: 10.1093/cvr/cvs296. Epub 2012 Sep 20. Cardiovasc Res. 2013. PMID: 22997158
Correlation network analysis for data integration and biomarker selection.
Adourian A, Jennings E, Balasubramanian R, Hines WM, Damian D, Plasterer TN, Clish CB, Stroobant P, McBurney R, Verheij ER, Bobeldijk I, van der Greef J, Lindberg J, Kenne K, Andersson U, Hellmold H, Nilsson K, Salter H, Schuppe-Koistinen I. Adourian A, et al. Among authors: andersson u. Mol Biosyst. 2008 Mar;4(3):249-59. doi: 10.1039/b708489g. Epub 2008 Jan 16. Mol Biosyst. 2008. PMID: 18437268
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
Munck Af Rosenschöld M, Johannesson P, Nikitidis A, Tyrchan C, Chang HF, Rönn R, Chapman D, Ullah V, Nikitidis G, Glader P, Käck H, Bonn B, Wågberg F, Björkstrand E, Andersson U, Swedin L, Rohman M, Andreasson T, Bergström EL, Jiang F, Zhou XH, Lundqvist AJ, Malmberg A, Ek M, Gordon E, Pettersen A, Ripa L, Davis AM. Munck Af Rosenschöld M, et al. Among authors: andersson u. J Med Chem. 2019 Sep 12;62(17):7769-7787. doi: 10.1021/acs.jmedchem.9b00555. Epub 2019 Aug 30. J Med Chem. 2019. PMID: 31415176
424 results