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Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.
Bergamaschi L, Mescia F, Turner L, Hanson AL, Kotagiri P, Dunmore BJ, Ruffieux H, De Sa A, Huhn O, Morgan MD, Gerber PP, Wills MR, Baker S, Calero-Nieto FJ, Doffinger R, Dougan G, Elmer A, Goodfellow IG, Gupta RK, Hosmillo M, Hunter K, Kingston N, Lehner PJ, Matheson NJ, Nicholson JK, Petrunkina AM, Richardson S, Saunders C, Thaventhiran JED, Toonen EJM, Weekes MP; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Göttgens B, Toshner M, Hess C, Bradley JR, Lyons PA, Smith KGC. Bergamaschi L, et al. Among authors: gottgens b. Immunity. 2021 Jun 8;54(6):1257-1275.e8. doi: 10.1016/j.immuni.2021.05.010. Epub 2021 May 16. Immunity. 2021. PMID: 34051148 Free PMC article.
Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation.
Calero-Nieto FJ, Wood AD, Wilson NK, Kinston S, Landry JR, Göttgens B. Calero-Nieto FJ, et al. Among authors: gottgens b. Nucleic Acids Res. 2010 Oct;38(19):6363-74. doi: 10.1093/nar/gkq490. Epub 2010 Jun 4. Nucleic Acids Res. 2010. PMID: 20525788 Free PMC article.
Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.
Moignard V, Macaulay IC, Swiers G, Buettner F, Schütte J, Calero-Nieto FJ, Kinston S, Joshi A, Hannah R, Theis FJ, Jacobsen SE, de Bruijn MF, Göttgens B. Moignard V, et al. Among authors: gottgens b. Nat Cell Biol. 2013 Apr;15(4):363-72. doi: 10.1038/ncb2709. Epub 2013 Mar 24. Nat Cell Biol. 2013. PMID: 23524953 Free PMC article.
Shared transcription factors contribute to distinct cell fates.
Ng FS, Calero-Nieto FJ, Göttgens B. Ng FS, et al. Among authors: gottgens b. Transcription. 2014;5(5):e978173. doi: 10.4161/21541264.2014.978173. Epub 2015 Jan 6. Transcription. 2014. PMID: 25425188 Free PMC article.
326 results