Bepler T - Search Results

1

Learning the protein language: Evolution, structure, and function.

Bepler T, Berger B. Bepler T, et al. Cell Syst. 2021 Jun 16;12(6):654-669.e3. doi: 10.1016/j.cels.2021.05.017. Cell Syst. 2021. PMID: 34139171 Free PMC article.

2

Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs.

Bepler T, Morin A, Noble AJ, Brasch J, Shapiro L, Berger B. Bepler T, et al. Res Comput Mol Biol. 2018 Apr;10812:245-247. Res Comput Mol Biol. 2018. PMID: 29707703 Free PMC article. No abstract available.

3

Visualization of clustered protocadherin neuronal self-recognition complexes.

Brasch J, Goodman KM, Noble AJ, Rapp M, Mannepalli S, Bahna F, Dandey VP, Bepler T, Berger B, Maniatis T, Potter CS, Carragher B, Honig B, Shapiro L. Brasch J, et al. Among authors: bepler t. Nature. 2019 May;569(7755):280-283. doi: 10.1038/s41586-019-1089-3. Epub 2019 Apr 10. Nature. 2019. PMID: 30971825 Free PMC article.

4

Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs.

Bepler T, Morin A, Rapp M, Brasch J, Shapiro L, Noble AJ, Berger B. Bepler T, et al. Nat Methods. 2019 Nov;16(11):1153-1160. doi: 10.1038/s41592-019-0575-8. Epub 2019 Oct 7. Nat Methods. 2019. PMID: 31591578 Free PMC article.

5

Topaz-Denoise: general deep denoising models for cryoEM and cryoET.

Bepler T, Kelley K, Noble AJ, Berger B. Bepler T, et al. Nat Commun. 2020 Oct 15;11(1):5208. doi: 10.1038/s41467-020-18952-1. Nat Commun. 2020. PMID: 33060581 Free PMC article.

6

CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks.

Zhong ED, Bepler T, Berger B, Davis JH. Zhong ED, et al. Among authors: bepler t. Nat Methods. 2021 Feb;18(2):176-185. doi: 10.1038/s41592-020-01049-4. Epub 2021 Feb 4. Nat Methods. 2021. PMID: 33542510 Free PMC article.

7

An engineered protein-phosphorylation toggle network with implications for endogenous network discovery.

Mishra D, Bepler T, Teague B, Berger B, Broach J, Weiss R. Mishra D, et al. Among authors: bepler t. Science. 2021 Jul 2;373(6550):eaav0780. doi: 10.1126/science.aav0780. Science. 2021. PMID: 34210851

8

Synthetic molecular evolution of antimicrobial peptides.

Chen CH, Bepler T, Pepper K, Fu D, Lu TK. Chen CH, et al. Among authors: bepler t. Curr Opin Biotechnol. 2022 Jun;75:102718. doi: 10.1016/j.copbio.2022.102718. Epub 2022 Apr 5. Curr Opin Biotechnol. 2022. PMID: 35395425 Review.

9

Learning to automate cryo-electron microscopy data collection with Ptolemy.

Kim PT, Noble AJ, Cheng A, Bepler T. Kim PT, et al. Among authors: bepler t. IUCrJ. 2023 Jan 1;10(Pt 1):90-102. doi: 10.1107/S2052252522010612. IUCrJ. 2023. PMID: 36598505 Free PMC article.

10

Machine learning optimization of candidate antibody yields highly diverse sub-nanomolar affinity antibody libraries.

Li L, Gupta E, Spaeth J, Shing L, Jaimes R, Engelhart E, Lopez R, Caceres RS, Bepler T, Walsh ME. Li L, et al. Among authors: bepler t. Nat Commun. 2023 Jun 12;14(1):3454. doi: 10.1038/s41467-023-39022-2. Nat Commun. 2023. PMID: 37308471 Free PMC article.

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