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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, Rajendra E, Ranzani M, Schaedler T, Stockley M, Wiggins K, Brough R, Sridhar S, Gulati A, Shao N, Badder LM, Novo D, Knight EG, Marlow R, Haider S, Callen E, Hewitt G, Schimmel J, Prevo R, Alli C, Ferdinand A, Bell C, Blencowe P, Bot C, Calder M, Charles M, Curry J, Ekwuru T, Ewings K, Krajewski W, MacDonald E, McCarron H, Pang L, Pedder C, Rigoreau L, Swarbrick M, Wheatley E, Willis S, Wong AC, Nussenzweig A, Tijsterman M, Tutt A, Boulton SJ, Higgins GS, Pettitt SJ, Smith GCM, Lord CJ. Zatreanu D, et al. Among authors: langdon s. Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8. Nat Commun. 2021. PMID: 34140467 Free PMC article.
PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activity.
Carnevalli LS, Sinclair C, Taylor MA, Gutierrez PM, Langdon S, Coenen-Stass AML, Mooney L, Hughes A, Jarvis L, Staniszewska A, Crafter C, Sidders B, Hardaker E, Hudson K, Barry ST. Carnevalli LS, et al. Among authors: langdon s. J Immunother Cancer. 2018 Dec 27;6(1):158. doi: 10.1186/s40425-018-0457-0. J Immunother Cancer. 2018. PMID: 30587236 Free PMC article.
In vitro and preclinical systematic dose-effect studies of Auger electron- and beta particle-emitting radionuclides and external beam radiation for cancer treatment.
Costa IM, Firth G, Kim J, Banu A, Pham TT, Sunassee K, Langdon S, De Santis V, Vass L, Schettino G, Fruhwirth GO, Terry SYA. Costa IM, et al. Among authors: langdon s. Int J Radiat Oncol Biol Phys. 2024 May 24:S0360-3016(24)00672-2. doi: 10.1016/j.ijrobp.2024.05.017. Online ahead of print. Int J Radiat Oncol Biol Phys. 2024. PMID: 38797497
Radiation Reveal: Moving from research engagement to involvement.
Whittaker L, Dean JA, Veiga C, Langdon S, Drake R, Taylor D, Williams MC, Masters H, Britton A, Cumbo M, Burdis N, Mason K, Fay G, Smith E, Benson S, Halil A, Lambert S, Gaze MN, Gains J, Spencer B, Taylor-Gee A, Terry SYA. Whittaker L, et al. Among authors: langdon s. Br J Cancer. 2024 Jun;130(10):1593-1598. doi: 10.1038/s41416-024-02648-0. Epub 2024 Apr 13. Br J Cancer. 2024. PMID: 38615107 Free PMC article. Review.
269 results