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Dnmt1 has de novo activity targeted to transposable elements.
Haggerty C, Kretzmer H, Riemenschneider C, Kumar AS, Mattei AL, Bailly N, Gottfreund J, Giesselmann P, Weigert R, Brändl B, Giehr P, Buschow R, Galonska C, von Meyenn F, Pappalardi MB, McCabe MT, Wittler L, Giesecke-Thiel C, Mielke T, Meierhofer D, Timmermann B, Müller FJ, Walter J, Meissner A. Haggerty C, et al. Among authors: mielke t. Nat Struct Mol Biol. 2021 Jul;28(7):594-603. doi: 10.1038/s41594-021-00603-8. Epub 2021 Jun 17. Nat Struct Mol Biol. 2021. PMID: 34140676 Free PMC article.
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium.
Brandt R, Sell T, Lüthen M, Uhlitz F, Klinger B, Riemer P, Giesecke-Thiel C, Schulze S, El-Shimy IA, Kunkel D, Fauler B, Mielke T, Mages N, Herrmann BG, Sers C, Blüthgen N, Morkel M. Brandt R, et al. Among authors: mielke t. Nat Commun. 2019 Jul 2;10(1):2919. doi: 10.1038/s41467-019-10954-y. Nat Commun. 2019. PMID: 31266962 Free PMC article.
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy.
van der Weijden VA, Stötzel M, Iyer DP, Fauler B, Gralinska E, Shahraz M, Meierhofer D, Vingron M, Rulands S, Alexandrov T, Mielke T, Bulut-Karslioglu A. van der Weijden VA, et al. Among authors: mielke t. Nat Cell Biol. 2024 Feb;26(2):181-193. doi: 10.1038/s41556-023-01325-3. Epub 2024 Jan 4. Nat Cell Biol. 2024. PMID: 38177284 Free PMC article.
Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.
Frauenfeld J, Gumbart J, Sluis EO, Funes S, Gartmann M, Beatrix B, Mielke T, Berninghausen O, Becker T, Schulten K, Beckmann R. Frauenfeld J, et al. Among authors: mielke t. Nat Struct Mol Biol. 2011 May;18(5):614-21. doi: 10.1038/nsmb.2026. Epub 2011 Apr 17. Nat Struct Mol Biol. 2011. PMID: 21499241 Free PMC article.
A critical period of translational control during brain development at codon resolution.
Harnett D, Ambrozkiewicz MC, Zinnall U, Rusanova A, Borisova E, Drescher AN, Couce-Iglesias M, Villamil G, Dannenberg R, Imami K, Münster-Wandowski A, Fauler B, Mielke T, Selbach M, Landthaler M, Spahn CMT, Tarabykin V, Ohler U, Kraushar ML. Harnett D, et al. Among authors: mielke t. Nat Struct Mol Biol. 2022 Dec;29(12):1277-1290. doi: 10.1038/s41594-022-00882-9. Epub 2022 Dec 8. Nat Struct Mol Biol. 2022. PMID: 36482253 Free PMC article.
Coupled chaperone action in folding and assembly of hexadecameric Rubisco.
Liu C, Young AL, Starling-Windhof A, Bracher A, Saschenbrecker S, Rao BV, Rao KV, Berninghausen O, Mielke T, Hartl FU, Beckmann R, Hayer-Hartl M. Liu C, et al. Among authors: mielke t. Nature. 2010 Jan 14;463(7278):197-202. doi: 10.1038/nature08651. Nature. 2010. PMID: 20075914
117 results