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Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom.
Török ME, Underwood BR, Toshner M, Waddington C, Sidhom E, Sharrocks K, Bousfield R, Summers C, Saunders C, McIntyre Z, Morris H, Piper J, Calderon G, Dennis S, Assari T, de Rotrou AM, Shaw A, Bradley J, O'Brien J, Rintoul RC, Smith I, Bullmore E, Chatterjee K; Cambridge COVID Vaccine Trial Team. Török ME, et al. Among authors: mcintyre z. Clin Trials. 2021 Oct;18(5):615-621. doi: 10.1177/17407745211024764. Epub 2021 Jun 22. Clin Trials. 2021. PMID: 34154428 Free PMC article.
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O'Reilly PJ, Padayachee SD, Pittella A, Plested E, Pollock KM, Ramasamy MN, Rhead S, Schwarzbold AV, Singh N, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Tarrant R, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Watson MEE, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group. Voysey M, et al. Lancet. 2021 Jan 9;397(10269):99-111. doi: 10.1016/S0140-6736(20)32661-1. Epub 2020 Dec 8. Lancet. 2021. PMID: 33306989 Free PMC article. Clinical Trial.
How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis.
Cunniffe NG, Gunter SJ, Brown M, Burge SW, Coyle C, De Soyza A, Dymond T, Esmail H, Francis DP, Galloway J, Galloway JB, Gkrania-Klotsas E, Greenaway J, Katritsis G, Kanagaratnam P, Knolle MD, Leonard K, McIntyre ZC, Prudon B, Rampling T, Torok ME, Warne B, Yates M, Matheson NJ, Su L, Villar S, Stewart GD, Toshner M. Cunniffe NG, et al. Among authors: mcintyre zc. BMJ Open. 2020 Oct 5;10(10):e044566. doi: 10.1136/bmjopen-2020-044566. BMJ Open. 2020. PMID: 33020111 Free PMC article.
Dexamethasone in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17. N Engl J Med. 2021. PMID: 32678530 Free PMC article. Clinical Trial.
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group; Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M, Ustianowski A, Elmahi E, Prudon B, Whitehouse T, Felton T, Williams J, Faccenda J, Underwood J, Baillie JK, Chappell LC, Faust SN, Jaki T, Jeffery K, Lim WS, Montgomery A, Rowan K, Tarning J, Watson JA, White NJ, Juszczak E, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2020 Nov 19;383(21):2030-2040. doi: 10.1056/NEJMoa2022926. Epub 2020 Oct 8. N Engl J Med. 2020. PMID: 33031652 Free PMC article. Clinical Trial.
Chronic pain is common in mitochondrial disease.
van den Ameele J, Fuge J, Pitceathly RDS, Berry S, McIntyre Z, Hanna MG, Lee M, Chinnery PF. van den Ameele J, et al. Among authors: mcintyre z. Neuromuscul Disord. 2020 May;30(5):413-419. doi: 10.1016/j.nmd.2020.02.017. Epub 2020 Feb 29. Neuromuscul Disord. 2020. PMID: 32334903 Free PMC article.
The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity.
Cambridge EL, McIntyre Z, Clare S, Arends MJ, Goulding D, Isherwood C, Caetano SS, Reviriego CB, Swiatkowska A, Kane L, Harcourt K; Sanger Mouse Genetics Project; Adams DJ, White JK, Speak AO. Cambridge EL, et al. Among authors: mcintyre z. Exp Hematol. 2017 Jan;45:64-68.e5. doi: 10.1016/j.exphem.2016.09.006. Epub 2016 Sep 22. Exp Hematol. 2017. PMID: 27666489 Free PMC article.
Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences.
Mottram L, Speak AO, Selek RM, Cambridge EL, McIntyre Z, Kane L, Mukhopadhyay S, Grove C, Colin A, Brandt C, Duque-Correa MA, Forbester J, Nguyen TA, Hale C, Vasilliou GS, Arends MJ, Wren BW, Dougan G, Clare S. Mottram L, et al. Among authors: mcintyre z. mBio. 2016 Jun 21;7(3):e00830-16. doi: 10.1128/mBio.00830-16. mBio. 2016. PMID: 27329747 Free PMC article.
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