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Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Schwabenland M, Salié H, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B. Schwabenland M, et al. Among authors: breithaupt a. Immunity. 2021 Jul 13;54(7):1594-1610.e11. doi: 10.1016/j.immuni.2021.06.002. Epub 2021 Jun 9. Immunity. 2021. PMID: 34174183 Free PMC article.
CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2.
Hoffmann D, Corleis B, Rauch S, Roth N, Mühe J, Halwe NJ, Ulrich L, Fricke C, Schön J, Kraft A, Breithaupt A, Wernike K, Michelitsch A, Sick F, Wylezich C, Hoffmann B, Thran M, Thess A, Mueller SO, Mettenleiter TC, Petsch B, Dorhoi A, Beer M. Hoffmann D, et al. Among authors: breithaupt a. Nat Commun. 2021 Jun 30;12(1):4048. doi: 10.1038/s41467-021-24339-7. Nat Commun. 2021. PMID: 34193869 Free PMC article.
Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta.
Ulrich L, Halwe NJ, Taddeo A, Ebert N, Schön J, Devisme C, Trüeb BS, Hoffmann B, Wider M, Fan X, Bekliz M, Essaidi-Laziosi M, Schmidt ML, Niemeyer D, Corman VM, Kraft A, Godel A, Laloli L, Kelly JN, Calderon BM, Breithaupt A, Wylezich C, Berenguer Veiga I, Gultom M, Osman S, Zhou B, Adea K, Meyer B, Eberhardt CS, Thomann L, Gsell M, Labroussaa F, Jores J, Summerfield A, Drosten C, Eckerle IA, Wentworth DE, Dijkman R, Hoffmann D, Thiel V, Beer M, Benarafa C. Ulrich L, et al. Among authors: breithaupt a. Nature. 2022 Feb;602(7896):307-313. doi: 10.1038/s41586-021-04342-0. Epub 2021 Dec 22. Nature. 2022. PMID: 34937050 Free PMC article.
Impaired immune response drives age-dependent severity of COVID-19.
Beer J, Crotta S, Breithaupt A, Ohnemus A, Becker J, Sachs B, Kern L, Llorian M, Ebert N, Labroussaa F, Nhu Thao TT, Trueeb BS, Jores J, Thiel V, Beer M, Fuchs J, Kochs G, Wack A, Schwemmle M, Schnepf D. Beer J, et al. Among authors: breithaupt a. J Exp Med. 2022 Dec 5;219(12):e20220621. doi: 10.1084/jem.20220621. Epub 2022 Sep 21. J Exp Med. 2022. PMID: 36129445 Free PMC article.
SARS-CoV-2 in fruit bats, ferrets, pigs, and chickens: an experimental transmission study.
Schlottau K, Rissmann M, Graaf A, Schön J, Sehl J, Wylezich C, Höper D, Mettenleiter TC, Balkema-Buschmann A, Harder T, Grund C, Hoffmann D, Breithaupt A, Beer M. Schlottau K, et al. Among authors: breithaupt a. Lancet Microbe. 2020 Sep;1(5):e218-e225. doi: 10.1016/S2666-5247(20)30089-6. Epub 2020 Jul 7. Lancet Microbe. 2020. PMID: 32838346 Free PMC article.
Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic.
Blaurock C, Breithaupt A, Weber S, Wylezich C, Keller M, Mohl BP, Görlich D, Groschup MH, Sadeghi B, Höper D, Mettenleiter TC, Balkema-Buschmann A. Blaurock C, et al. Among authors: breithaupt a. Sci Rep. 2022 Sep 5;12(1):15069. doi: 10.1038/s41598-022-19222-4. Sci Rep. 2022. PMID: 36064749 Free PMC article.
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype.
Barut GT, Halwe NJ, Taddeo A, Kelly JN, Schön J, Ebert N, Ulrich L, Devisme C, Steiner S, Trüeb BS, Hoffmann B, Veiga IB, Leborgne NGF, Moreira EA, Breithaupt A, Wylezich C, Höper D, Wernike K, Godel A, Thomann L, Flück V, Stalder H, Brügger M, Esteves BIO, Zumkehr B, Beilleau G, Kratzel A, Schmied K, Ochsenbein S, Lang RM, Wider M, Machahua C, Dorn P, Marti TM, Funke-Chambour M, Rauch A, Widera M, Ciesek S, Dijkman R, Hoffmann D, Alves MP, Benarafa C, Beer M, Thiel V. Barut GT, et al. Among authors: breithaupt a. Nat Commun. 2022 Oct 7;13(1):5929. doi: 10.1038/s41467-022-33632-y. Nat Commun. 2022. PMID: 36207334 Free PMC article.
104 results