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Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.
Ogishi M, Yang R, Aytekin C, Langlais D, Bourgey M, Khan T, Ali FA, Rahman M, Delmonte OM, Chrabieh M, Zhang P, Gruber C, Pelham SJ, Spaan AN, Rosain J, Lei WT, Drutman S, Hellmann MD, Callahan MK, Adamow M, Wong P, Wolchok JD, Rao G, Ma CS, Nakajima Y, Yaguchi T, Chamoto K, Williams SC, Emile JF, Rozenberg F, Glickman MS, Rapaport F, Kerner G, Allington G, Tezcan I, Cagdas D, Hosnut FO, Dogu F, Ikinciogullari A, Rao VK, Kainulainen L, Béziat V, Bustamante J, Vilarinho S, Lifton RP, Boisson B, Abel L, Bogunovic D, Marr N, Notarangelo LD, Tangye SG, Honjo T, Gros P, Boisson-Dupuis S, Casanova JL. Ogishi M, et al. Among authors: nakajima y. Nat Med. 2021 Sep;27(9):1646-1654. doi: 10.1038/s41591-021-01388-5. Epub 2021 Jun 28. Nat Med. 2021. PMID: 34183838 Free PMC article.
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.
Al-Habsi M, Chamoto K, Matsumoto K, Nomura N, Zhang B, Sugiura Y, Sonomura K, Maharani A, Nakajima Y, Wu Y, Nomura Y, Menzies R, Tajima M, Kitaoka K, Haku Y, Delghandi S, Yurimoto K, Matsuda F, Iwata S, Ogura T, Fagarasan S, Honjo T. Al-Habsi M, et al. Among authors: nakajima y. Science. 2022 Oct 28;378(6618):eabj3510. doi: 10.1126/science.abj3510. Epub 2022 Oct 28. Science. 2022. PMID: 36302005
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
Kajiro M, Hirota R, Nakajima Y, Kawanowa K, So-ma K, Ito I, Yamaguchi Y, Ohie SH, Kobayashi Y, Seino Y, Kawano M, Kawabe Y, Takei H, Hayashi S, Kurosumi M, Murayama A, Kimura K, Yanagisawa J. Kajiro M, et al. Among authors: nakajima y. Nat Cell Biol. 2009 Mar;11(3):312-9. doi: 10.1038/ncb1839. Epub 2009 Feb 8. Nat Cell Biol. 2009. PMID: 19198599 Free article.
PPARgamma ligands suppress the feedback loop between E2F2 and cyclin-E1.
Komatsu Y, Ito I, Wayama M, Fujimura A, Akaogi K, Machida H, Nakajima Y, Kuroda T, Ohmori K, Murayama A, Kimura K, Yanagisawa J. Komatsu Y, et al. Among authors: nakajima y. Biochem Biophys Res Commun. 2008 May 23;370(1):145-8. doi: 10.1016/j.bbrc.2008.03.046. Epub 2008 Mar 18. Biochem Biophys Res Commun. 2008. PMID: 18355447
Estrogen inhibits transforming growth factor beta signaling by promoting Smad2/3 degradation.
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J. Ito I, et al. Among authors: nakajima y. J Biol Chem. 2010 May 7;285(19):14747-55. doi: 10.1074/jbc.M109.093039. Epub 2010 Mar 5. J Biol Chem. 2010. PMID: 20207742 Free PMC article.
Novel nucleolar pathway connecting intracellular energy status with p53 activation.
Kumazawa T, Nishimura K, Kuroda T, Ono W, Yamaguchi C, Katagiri N, Tsuchiya M, Masumoto H, Nakajima Y, Murayama A, Kimura K, Yanagisawa J. Kumazawa T, et al. Among authors: nakajima y. J Biol Chem. 2011 Jun 10;286(23):20861-9. doi: 10.1074/jbc.M110.209916. Epub 2011 Apr 6. J Biol Chem. 2011. PMID: 21471221 Free PMC article.
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
Kajiro M, Tsuchiya M, Kawabe Y, Furumai R, Iwasaki N, Hayashi Y, Katano M, Nakajima Y, Goto N, Watanabe T, Murayama A, Oishi H, Ema M, Takahashi S, Kishimoto H, Yanagisawa J. Kajiro M, et al. Among authors: nakajima y. PLoS One. 2011;6(10):e25871. doi: 10.1371/journal.pone.0025871. Epub 2011 Oct 18. PLoS One. 2011. PMID: 22028794 Free PMC article.
3,592 results