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CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis.
Gillmore JD, Gane E, Taubel J, Kao J, Fontana M, Maitland ML, Seitzer J, O'Connell D, Walsh KR, Wood K, Phillips J, Xu Y, Amaral A, Boyd AP, Cehelsky JE, McKee MD, Schiermeier A, Harari O, Murphy A, Kyratsous CA, Zambrowicz B, Soltys R, Gutstein DE, Leonard J, Sepp-Lorenzino L, Lebwohl D. Gillmore JD, et al. Among authors: murphy a. N Engl J Med. 2021 Aug 5;385(6):493-502. doi: 10.1056/NEJMoa2107454. Epub 2021 Jun 26. N Engl J Med. 2021. PMID: 34215024 Clinical Trial.
A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells.
Cruz JW, Damko E, Modi B, Tu N, Meagher K, Voronina V, Gartner H, Ehrlich G, Rafique A, Babb R, Aneja P, Potocky TB, D' Orvilliers A, Coppi A, E SY, Qiu H, Williams CM, Bennett BL, Chen G, Macdonald L, Olson W, Lin JC, Stahl N, Murphy AJ, Kyratsous CA, Prasad BC. Cruz JW, et al. Among authors: murphy aj. Sci Rep. 2019 Aug 19;9(1):12031. doi: 10.1038/s41598-019-48461-1. Sci Rep. 2019. PMID: 31427700 Free PMC article.
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.
Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, Yan Y, Koon K, Patel K, Chung KM, Hermann A, Ullman E, Cruz J, Rafique A, Huang T, Fairhurst J, Libertiny C, Malbec M, Lee WY, Welsh R, Farr G, Pennington S, Deshpande D, Cheng J, Watty A, Bouffard P, Babb R, Levenkova N, Chen C, Zhang B, Romero Hernandez A, Saotome K, Zhou Y, Franklin M, Sivapalasingam S, Lye DC, Weston S, Logue J, Haupt R, Frieman M, Chen G, Olson W, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA. Hansen J, et al. Among authors: murphy aj. Science. 2020 Aug 21;369(6506):1010-1014. doi: 10.1126/science.abd0827. Epub 2020 Jun 15. Science. 2020. PMID: 32540901 Free PMC article.
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.
Baum A, Ajithdoss D, Copin R, Zhou A, Lanza K, Negron N, Ni M, Wei Y, Mohammadi K, Musser B, Atwal GS, Oyejide A, Goez-Gazi Y, Dutton J, Clemmons E, Staples HM, Bartley C, Klaffke B, Alfson K, Gazi M, Gonzalez O, Dick E Jr, Carrion R Jr, Pessaint L, Porto M, Cook A, Brown R, Ali V, Greenhouse J, Taylor T, Andersen H, Lewis MG, Stahl N, Murphy AJ, Yancopoulos GD, Kyratsous CA. Baum A, et al. Among authors: murphy aj. Science. 2020 Nov 27;370(6520):1110-1115. doi: 10.1126/science.abe2402. Epub 2020 Oct 9. Science. 2020. PMID: 33037066 Free PMC article.
Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054.
Tavaré R, Danton M, Giurleo JT, Makonnen S, Hickey C, Arnold TC, Kelly MP, Fredriksson F, Bruestle K, Hermann A, Ullman E, Edelmann KH, Potocky T, Dudgeon D, Bhatt NB, Doubrovin M, Barry T, Kyratsous CA, Gurer C, Tu N, Gartner H, Murphy A, Macdonald LE, Popke J, Mintz A, Griesemer A, Olson WC, Thurston G, Ma D, Kirshner JR. Tavaré R, et al. Among authors: murphy a. Cancer Immunol Res. 2022 Oct 4;10(10):1190-1209. doi: 10.1158/2326-6066.CIR-21-0405. Cancer Immunol Res. 2022. PMID: 35895745 Free PMC article.
IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models.
Carbonaro M, Wang K, Huang H, Frleta D, Patel A, Pennington A, Desclaux M, Moller-Tank S, Grindley J, Altarejos J, Zhong J, Polites G, Poueymirou W, Jaspers S, Kyratsous C, Zambrowicz B, Murphy A, Lin JC, Macdonald LE, Daly C, Sleeman M, Thurston G, Li Z. Carbonaro M, et al. Among authors: murphy a. Sci Adv. 2023 Apr 14;9(15):eadf4490. doi: 10.1126/sciadv.adf4490. Epub 2023 Apr 14. Sci Adv. 2023. PMID: 37058568 Free PMC article.
A therapeutic strategy to target distinct sources of IgE and durably reverse allergy.
Limnander A, Kaur N, Asrat S, Tasker C, Boyapati A, Ben LH, Janczy J, Pedraza P, Abreu P, Chen WC, Godin S, Daniel BJ, Chin H, DeVeaux M, Rodriguez Lorenc K, Sirulnik A, Harari O, Stahl N, Sleeman MA, Murphy AJ, Yancopoulos GD, Orengo JM. Limnander A, et al. Among authors: murphy aj. Sci Transl Med. 2023 Dec 13;15(726):eadf9561. doi: 10.1126/scitranslmed.adf9561. Epub 2023 Dec 13. Sci Transl Med. 2023. PMID: 38091405
C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.
Atanasio A, Decman V, White D, Ramos M, Ikiz B, Lee HC, Siao CJ, Brydges S, LaRosa E, Bai Y, Fury W, Burfeind P, Zamfirova R, Warshaw G, Orengo J, Oyejide A, Fralish M, Auerbach W, Poueymirou W, Freudenberg J, Gong G, Zambrowicz B, Valenzuela D, Yancopoulos G, Murphy A, Thurston G, Lai KM. Atanasio A, et al. Among authors: murphy a. Sci Rep. 2016 Mar 16;6:23204. doi: 10.1038/srep23204. Sci Rep. 2016. PMID: 26979938 Free PMC article.
3,699 results