Haigis M - Search Results

1

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.

Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N. Wagner A, et al. Among authors: haigis m. Cell. 2021 Aug 5;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 2. Cell. 2021. PMID: 34216539 Free PMC article.

2

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.

Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC. Finley LW, et al. Among authors: haigis mc. Cancer Cell. 2011 Mar 8;19(3):416-28. doi: 10.1016/j.ccr.2011.02.014. Cancer Cell. 2011. PMID: 21397863 Free PMC article.

3

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction.

Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Finley LW, et al. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2931-6. doi: 10.1073/pnas.1115813109. Epub 2012 Feb 3. Proc Natl Acad Sci U S A. 2012. PMID: 22308395 Free PMC article.

4

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.

Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC. Jeong SM, et al. Cancer Cell. 2013 Apr 15;23(4):450-63. doi: 10.1016/j.ccr.2013.02.024. Epub 2013 Apr 4. Cancer Cell. 2013. PMID: 23562301 Free PMC article.

5

Mitochondrial metabolism in T cell activation and senescence: a mini-review.

Ron-Harel N, Sharpe AH, Haigis MC. Ron-Harel N, et al. Gerontology. 2015;61(2):131-8. doi: 10.1159/000362502. Epub 2014 Nov 13. Gerontology. 2015. PMID: 25402204 Free article. Review.

6

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Ron-Harel N, et al. Among authors: haigis mc. Cell Metab. 2016 Jul 12;24(1):104-17. doi: 10.1016/j.cmet.2016.06.007. Cell Metab. 2016. PMID: 27411012 Free PMC article.

7

Suppression by T_FR cells leads to durable and selective inhibition of B cell effector function.

Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Sage PT, et al. Among authors: haigis m. Nat Immunol. 2016 Dec;17(12):1436-1446. doi: 10.1038/ni.3578. Epub 2016 Oct 3. Nat Immunol. 2016. PMID: 27695002 Free PMC article.

8

Strength in numbers: Phosphofructokinase polymerization prevails in the liver.

Zaganjor E, Spinelli JB, Haigis MC. Zaganjor E, et al. J Cell Biol. 2017 Aug 7;216(8):2239-2241. doi: 10.1083/jcb.201706005. Epub 2017 Jul 17. J Cell Biol. 2017. PMID: 28716843 Free PMC article.

9

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.

Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, Haigis MC. Spinelli JB, et al. Science. 2017 Nov 17;358(6365):941-946. doi: 10.1126/science.aam9305. Epub 2017 Oct 12. Science. 2017. PMID: 29025995 Free PMC article.

10

Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.

Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Gonzalez Herrera KN, et al. Among authors: haigis mc. Cell Rep. 2018 Feb 20;22(8):1945-1955. doi: 10.1016/j.celrep.2018.01.076. Cell Rep. 2018. PMID: 29466723 Free PMC article.

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