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Page 1
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.
Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N. Wagner A, et al. Among authors: puleston d. Cell. 2021 Aug 5;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 2. Cell. 2021. PMID: 34216539 Free PMC article.
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy.
Klein Geltink RI, Edwards-Hicks J, Apostolova P, O'Sullivan D, Sanin DE, Patterson AE, Puleston DJ, Ligthart NAM, Buescher JM, Grzes KM, Kabat AM, Stanczak M, Curtis JD, Hässler F, Uhl FM, Fabri M, Zeiser R, Pearce EJ, Pearce EL. Klein Geltink RI, et al. Among authors: puleston dj. Nat Metab. 2020 Aug;2(8):703-716. doi: 10.1038/s42255-020-0256-z. Epub 2020 Aug 3. Nat Metab. 2020. PMID: 32747793 Free PMC article.
Fever supports CD8+ effector T cell responses by promoting mitochondrial translation.
O'Sullivan D, Stanczak MA, Villa M, Uhl FM, Corrado M, Klein Geltink RI, Sanin DE, Apostolova P, Rana N, Edwards-Hicks J, Grzes KM, Kabat AM, Kyle RL, Fabri M, Curtis JD, Buck MD, Patterson AE, Regina A, Field CS, Baixauli F, Puleston DJ, Pearce EJ, Zeiser R, Pearce EL. O'Sullivan D, et al. Among authors: puleston dj. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2023752118. doi: 10.1073/pnas.2023752118. Epub 2021 Jun 14. Proc Natl Acad Sci U S A. 2021. PMID: 34161266 Free PMC article.
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kamiński MM, Stanckzak M, Weiss HJ, Grzes KM, Piletic K, Field CS, Corrado M, Haessler F, Wang C, Musa Y, Schimmelpfennig L, Flachsmann L, Mittler G, Yosef N, Kuchroo VK, Buescher JM, Balabanov S, Pearce EJ, Green DR, Pearce EL. Puleston DJ, et al. Cell. 2021 Aug 5;184(16):4186-4202.e20. doi: 10.1016/j.cell.2021.06.007. Epub 2021 Jul 2. Cell. 2021. PMID: 34216540 Free PMC article.
An LKB1-mitochondria axis controls TH17 effector function.
Baixauli F, Piletic K, Puleston DJ, Villa M, Field CS, Flachsmann LJ, Quintana A, Rana N, Edwards-Hicks J, Matsushita M, Stanczak MA, Grzes KM, Kabat AM, Fabri M, Caputa G, Kelly B, Corrado M, Musa Y, Duda KJ, Mittler G, O'Sullivan D, Sesaki H, Jenuwein T, Buescher JM, Pearce EJ, Sanin DE, Pearce EL. Baixauli F, et al. Among authors: puleston dj. Nature. 2022 Oct;610(7932):555-561. doi: 10.1038/s41586-022-05264-1. Epub 2022 Sep 28. Nature. 2022. PMID: 36171294 Free PMC article.
Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment.
Villa M, Sanin DE, Apostolova P, Corrado M, Kabat AM, Cristinzio C, Regina A, Carrizo GE, Rana N, Stanczak MA, Baixauli F, Grzes KM, Cupovic J, Solagna F, Hackl A, Globig AM, Hässler F, Puleston DJ, Kelly B, Cabezas-Wallscheid N, Hasselblatt P, Bengsch B, Zeiser R, Sagar, Buescher JM, Pearce EJ, Pearce EL. Villa M, et al. Among authors: puleston dj. Nat Commun. 2024 Jan 11;15(1):451. doi: 10.1038/s41467-024-44689-2. Nat Commun. 2024. PMID: 38200005 Free PMC article.
30 results