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Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study.
Clin Gastroenterol Hepatol. 2024 Mar 4:S1542-3565(24)00226-X. doi: 10.1016/j.cgh.2024.02.022. Online ahead of print.
Clin Gastroenterol Hepatol. 2024.
PMID: 38447814
Free article.
Safety and efficacy of once-weekly efruxifermin versus placebo in non-alcoholic steatohepatitis (HARMONY): a multicentre, randomised, double-blind, placebo-controlled, phase 2b trial.
Harrison SA, Frias JP, Neff G, Abrams GA, Lucas KJ, Sanchez W, Gogia S, Sheikh MY, Behling C, Bedossa P, Shao L, Chan D, Fong E, de Temple B, Shringarpure R, Tillman EJ, Rolph T, Cheng A, Yale K; HARMONY Study Group.
Harrison SA, et al. Among authors: de temple b.
Lancet Gastroenterol Hepatol. 2023 Dec;8(12):1080-1093. doi: 10.1016/S2468-1253(23)00272-8. Epub 2023 Oct 3.
Lancet Gastroenterol Hepatol. 2023.
PMID: 37802088
Clinical Trial.
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Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin.
Kinne AS, Tillman EJ, Abdeen SJ, Johnson DE, Parmer ES, Hurst JP, de Temple B, Rinker S, Rolph TP, Bowsher RR.
Kinne AS, et al. Among authors: de temple b.
J Pharm Biomed Anal. 2023 Aug 5;232:115402. doi: 10.1016/j.jpba.2023.115402. Epub 2023 Apr 18.
J Pharm Biomed Anal. 2023.
PMID: 37141854
Free article.
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A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis.
Harrison SA, Ruane PJ, Freilich B, Neff G, Patil R, Behling C, Hu C, Shringarpure R, de Temple B, Fong E, Tillman EJ, Rolph T, Cheng A, Yale K.
Harrison SA, et al. Among authors: de temple b.
JHEP Rep. 2022 Aug 23;5(1):100563. doi: 10.1016/j.jhepr.2022.100563. eCollection 2023 Jan.
JHEP Rep. 2022.
PMID: 36644237
Free PMC article.
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Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial.
Harrison SA, Ruane PJ, Freilich BL, Neff G, Patil R, Behling CA, Hu C, Fong E, de Temple B, Tillman EJ, Rolph TP, Cheng A, Yale K.
Harrison SA, et al. Among authors: de temple b.
Nat Med. 2021 Jul;27(7):1262-1271. doi: 10.1038/s41591-021-01425-3. Epub 2021 Jul 8.
Nat Med. 2021.
PMID: 34239138
Clinical Trial.
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