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Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Hu T, et al. Among authors: auwerx j. Gastroenterology. 2021 Nov;161(5):1584-1600. doi: 10.1053/j.gastro.2021.06.045. Epub 2021 Jul 8. Gastroenterology. 2021. PMID: 34245764 Free PMC article.
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Dikalova AE, Pandey A, Xiao L, Arslanbaeva L, Sidorova T, Lopez MG, Billings FT 4th, Verdin E, Auwerx J, Harrison DG, Dikalov SI. Dikalova AE, et al. Among authors: auwerx j. Circ Res. 2020 Feb 14;126(4):439-452. doi: 10.1161/CIRCRESAHA.119.315767. Epub 2019 Dec 19. Circ Res. 2020. PMID: 31852393 Free PMC article.
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, Maymi V, Dhawan R, Auwerx J, Southard T, Cerione RA, Lin H, Weiss RS. Abril YLN, et al. Among authors: auwerx j. Oncogene. 2021 Mar;40(9):1644-1658. doi: 10.1038/s41388-020-01637-w. Epub 2021 Jan 21. Oncogene. 2021. PMID: 33479498 Free PMC article.
The intestinal nuclear receptor signature with epithelial localization patterns and expression modulation in tumors.
Modica S, Gofflot F, Murzilli S, D'Orazio A, Salvatore L, Pellegrini F, Nicolucci A, Tognoni G, Copetti M, Valanzano R, Veschi S, Mariani-Costantini R, Palasciano G, Schoonjans K, Auwerx J, Moschetta A. Modica S, et al. Among authors: auwerx j. Gastroenterology. 2010 Feb;138(2):636-48, 648.e1-12. doi: 10.1053/j.gastro.2009.09.060. Epub 2009 Oct 8. Gastroenterology. 2010. PMID: 19818784
Mitochondrial sirtuins and metabolic homeostasis.
Pirinen E, Lo Sasso G, Auwerx J. Pirinen E, et al. Among authors: auwerx j. Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):759-70. doi: 10.1016/j.beem.2012.05.001. Epub 2012 May 31. Best Pract Res Clin Endocrinol Metab. 2012. PMID: 23168278 Free PMC article. Review.
Metabolic characterization of a Sirt5 deficient mouse model.
Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J. Yu J, et al. Among authors: auwerx j. Sci Rep. 2013 Sep 30;3:2806. doi: 10.1038/srep02806. Sci Rep. 2013. PMID: 24076663 Free PMC article.
629 results